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The Autoimmune Tautology: An In Silico Approach
dc.audience | Comunidad Rosarista | spa |
dc.creator | Cifuentes, Ricardo | |
dc.creator | Restrepo-Montoya, Daniel | |
dc.creator | Anaya, Juan-Manuel | |
dc.creator.google | Cifuentes, Ricardo A. | |
dc.creator.google | Restrepo-Montoya, Daniel | |
dc.creator.google | Anaya, Juan-Manuel | |
dc.date.accessioned | 2014-08-11T20:31:28Z | |
dc.date.available | 2014-08-11T20:31:28Z | |
dc.date.created | 2012 | |
dc.date.issued | 2012 | |
dc.description.abstract | There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sjögren’s syndrome—systemic lupus erythematosus, and autoimmune thyroid disease—type1 diabetes—rheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10. | eng |
dc.format.medium | Recurso electrónico | spa |
dc.format.mimetype | application/pdf | |
dc.format.tipo | Documento | spa |
dc.identifier.issn | ISSN:2090-0430 | |
dc.identifier.uri | http://repository.urosario.edu.co/handle/10336/8778 | |
dc.language.iso | eng | |
dc.publisher | Universidad del Rosario | spa |
dc.relation.citationTitle | Autoimmune Diseases | |
dc.relation.ispartof | Autoimmune Diseases, ISSN 2090-04-30, 2012 | spa |
dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
dc.rights.acceso | Abierto (Texto completo) | spa |
dc.rights.licencia | EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. | spa |
dc.source.instname | instname:Universidad del Rosario | spa |
dc.source.reponame | reponame:Repositorio Institucional EdocUR | spa |
dc.subject.ddc | Enfermedades | |
dc.subject.decs | Enfermedades autoinmunes | spa |
dc.subject.decs | Inmunología | spa |
dc.subject.decs | Sida | spa |
dc.subject.decs | Diabetes | spa |
dc.title | The Autoimmune Tautology: An In Silico Approach | spa |
dc.type | article | eng |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | |
dc.type.spa | Artículo | spa |
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