Ítem
Acceso Abierto

Rendimiento de la proteína ligadora de ácidos grasos del miocito para el diagnóstico de infarto de miocardio

Mostrar el registro sencillo de la publicación
dc.contributor.advisorIsaza-Restrepo, Daniel
dc.contributor.advisorDennis Verano, Rodolfo José
dc.creatorIdrovo Turbay, Álvaro Enrique
dc.creatorCortes-Puentes, Luis Arcadio
dc.creatorAldana, Víctor
dc.creatorVasquez, Sergio
dc.creatorIsaza, Daniel
dc.creatorDennis Verano, Rodolfo José
dc.creator.degreeEspecialista en Cardiología
dc.date.accessioned2017-02-22T16:14:32Z
dc.date.available2017-02-22T16:14:32Z
dc.date.created2017-02
dc.date.issued2017
dc.descriptionObjetivo: Evaluar la eficacia diagnóstica de CardioDetect (Proteína ligadora de ácidos grasos del miocito) contra la troponina I en la detección temprana del Infarto Agudo de Miocardio, en un grupo de pacientes con dolor torácico típico agudo en el servicio urgencias de la Fundación Cardioinfantil – Instituto de Cardiología. Métodos: Estudio de prueba diagnóstica, de corte transversal en el servicio de urgencias de la Fundación Cardioinfantil – Instituto de Cardiología. Se evaluó el rendimiendo diagnóstico de la proteína ligadora de ácidos grasos del miocito en 38 pacientes (28 pacientes con diagnóstico de infarto agudo de miocardio y 10 pacientes con diagnóstico de angina inestable) quienes consultaron al servicio de urgencias de la Fundación Cardioinfantil dentro de las 3 pimeras horas de inicio de los síntomas. Resultados: El promedio de edad fue de 63 años. De los 28 pacientes con síndrome coronario tipo infarto agudo de miocardio, Cardiodetect® resultó positiva en 27 ocasiones, mientras que resultó positiva en 1 de 10 pacientes con diagnóstico final de angina inestable, calculándose sensibilidad y valor predictivo positivo de 96.4%, especificidad y valor predictivo negativo de 90%, LR positivo 9.64 y LR negativo 0.04. En cuanto a la troponina, de los 28 pacientes con infarto agudo de miocardio, mostró positividad en 15 casos mientras en los pacientes con diagnóstico final de angina inestable no hubo positividad en ningún paciente, calculándose entonces sensibilidad del 53%, especificidad de 100%, VPP 100% y valor predictivo negativo 43.5%.spa
dc.description.abstractObjective To evaluate the diagnostic efficacy of CardioDetect (Heart type fatty acid binding protein) against Troponin I in the early detection of myocardial infarction in patients with acute chest pain in the emergency department of the Cardioinfantil Foundation – Cardiology Institute . Materials and methods: Diagnostic test study, cross-sectional in the emergency department of the Cardioinfantil Foundation - Cardiology Institute. The diagnostic performance of the myocyte fatty acid binding protein was evaluated in 38 patients (28 patients with a diagnosis of acute myocardial infarction and 10 patients with a diagnosis of unstable angina) who consulted the emergency department of the Cardioinfantil Foundation within 3 first hours of onset of symptoms. Results: The average age was 63 years. Of the 28 patients with acute myocardial infarction coronary syndrome, Cardiodetect® was positive in 27 occasions, while it was positive in 1 of 10 patients with a final diagnosis of unstable angina, with a sensitivity and a positive predictive value of 96. 4%, specificity and value Predictive negative of 90%, likelihood ratio positive 9. 64 and likelihood ratio negative 0. 04. As for troponin, of the 28 patients with acute myocardial infarction, it showed positivity in 15 cases, whereas in patients with a final diagnosis of unstable angina, there was no positivity in any patient, with a sensitivity of 53%, specificity of 100% Positive predictive value of 100%, negative predictive value of 43. 5%. eng
dc.description.sponsorshiplaboratorio Biopassspa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_13063
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/13063
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Cardiologíaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.source.bibliographicCitation1. Pope HJ, Aufderheide TP, Ruthazer R, et al. Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med 2000;342:1163-70.
dc.source.bibliographicCitation2. GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993;329:673-82.
dc.source.bibliographicCitation3. Centers for Disease Control and Prevention, National Center for Health Statistics. Compressed Mortality File 1999-2007. CDC WONDER On-line Database, compiled from Compressed Mortality File 1999-2007 Series 20 No. 2K, 2008. Accessed on: http://wonder.cdc.gov/cmf-icd10.html on Feb 20, 2011.
dc.source.bibliographicCitation4. Zipes DP, Wellens HJJ. Sudden cardiac death. Circulation 1998;98:2334-51.
dc.source.bibliographicCitation5. Bertrand ME, Simoons ML, Fox KAA, et al. Management of acute coronary syndromes: Acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 2000;21:1406-32.
dc.source.bibliographicCitation6. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation 2007;116:2634-53.
dc.source.bibliographicCitation7. Anderson JL, Adams CD, Antman EM, et al: ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): Developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation 2007; 116:e148.
dc.source.bibliographicCitation8. Antman EM, Anbe DT, Armstrong PW, et al: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation 2004; 110:e82.
dc.source.bibliographicCitation9. Blomkalns AL, Gibler WB: Chest pain unit concept: rationale and diagnostic strategies. Cardiol Clin 2005; 23:411.
dc.source.bibliographicCitation10. Morrow DA: Clinical application of sensitive troponin assays. N Engl J Med 2009; 361:913.
dc.source.bibliographicCitation11. Morrow DA, Cannon CP, Jesse RL, et al: National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation 2007; 115:e356.
dc.source.bibliographicCitation12. Wu AH, Jaffe AS, Apple FS, et al: National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin Chem 2007; 53:2086.
dc.source.bibliographicCitation13. Keller T, Zeller T, Peetz D, et al: Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009; 61:868.
dc.source.bibliographicCitation14. Puleo PR, Meyer D, Watchen C, et al. Use of a rapid assay of subforms of creatine kinase MB to diagnose to rule out acute myocardial infarctation. N Engl J Med 1994;331:561-66.
dc.source.bibliographicCitation15. Fesmire FM, Christenson RH, Fody EP, et al. Delta creatine kinase-MB outperforms myoglobin at two hours during the emergency department identification and exclusion of troponin positive non-ST-segment elevation acute coronary syndromes. Ann Emerg Med 2004;44:12-9.
dc.source.bibliographicCitation16. Ghani F, Wu AH, Graff L, et al. Role of heart-type fatty acid-binding protein in early detection of acute myocardial infarction. Clin Chem 2000;46:718-9.
dc.source.bibliographicCitation17. Ruzgar O, Bilge AK et al. The use of human heart-type fatty acid-binding protein as an early diagnostic biochemical marker of myocardial necrosis in patients with acute coronary syndrome, and its comparison with troponin-T and creatine kinase–myocardial band. Heart Vessels 2006;21:309–14.
dc.source.bibliographicCitation18. Bhagavan NV, Ha JS, Park JH, et al. Utility of serum Fatty Acid concentrations as a marker for acute myocardial infarction and their potential role in the formation of ischemia-modified albumin: a pilot study. Clin Chem. 2009;55:1588-90.
dc.source.bibliographicCitation19. Seino Y, Ogata K, Takano T, et al. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med 2003;115:185-90.
dc.source.bibliographicCitation20. Bruins Slot MH, van der Heijden GJ, Rutten FH, et al. Heart-type Fatty acid-binding protein in Acute Myocardial infarction Evaluation (FAME): background and design of a diagnostic study in primary care. BMC Cardiovasc Disord 2008;8:8-13
dc.source.bibliographicCitation21. Tong CY, Chan CP, Cheung KY et al. A point-of-care immunotest for bedside determination of heart-type fatty acid-binding protein. Analytical Letters 2010;43:735-44.
dc.source.bibliographicCitation22. Kabekkodu S, Mananje S, Saya R. A study on the role of heart type fatty acid binding protein in the diagnosis of acute myocardial infarction. Journal of Clinical and Diagnostic Research 2016;10: 7 – 10.
dc.source.bibliographicCitation23. Pyati A, Devaranavadagi B, Sajjannar S, et al. Heart Type Fatty Acid Binding Protein: A better cardiac biomarker than CK – MB and myoglobin in the early diagnosis of acute myocardial infarction. Journal of Clinical and Diagnostic Research 2015;9: 8 – 11.
dc.source.bibliographicCitation24. Reiter M, Twerenbold R, Reichlin T, et al. Heart type fatty acid binding protein in the early diagnosis of acute myocardial infarction. Heart 2013;99:708-714.
dc.source.bibliographicCitation25. Schoenenberger A, Stallone F, Walz B, et al. Incremental value of heart type fatty acid binding protein in suspected acute myocardial infarction early after symptoms onset. Eur Heart J Acute Cardiovasc Care 2016;5(2):185-92.
dc.source.bibliographicCitation26. Danese E, Montagnana M. An historical approach to the diagnostic biomarkers of acute coronary syndrome. Am Transl Med 2016;4(10): 1 – 11.
dc.source.bibliographicCitation27. Ladue JS, Wröblewski F, Karmen A. Serum glutamic oxaloacetic transaminase activity in human acute myocardial infarction. Science 1954; 120:497 – 9.
dc.source.bibliographicCitation28. Ulmer DD, Valle BL, Wacker WE. Metalloenzymes and myocardial infarction. Malic an lactic dehydrogenase activities and zinc concentrations in serum. N Engl J Med 1956;255:450 – 6.
dc.source.bibliographicCitation29. Dreyfus JC, Schapira G, Rasnais J, et al. Serum creatine kinase in the diagnosis of myocardial infarct. Rev Fr Etud Clin Biol 1960;5: 386-7.
dc.source.bibliographicCitation30. Giannitsis E, Kurz K, Hallermayer K, et al. Analytical validation of a high sensitivity cardiac troponin T assay. Clin Chem 2010;56:254 – 61.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectProteína ligadora de ácidos grasos del miocitospa
dc.subjectTroponinaspa
dc.subjectSindrome coronario agudospa
dc.subject.ddcEnfermedades
dc.subject.decsCardiomiopatíasspa
dc.subject.decsProteína de Unión a Andrógenos -- Funcionamientospa
dc.subject.decsInfarto -- Investigacionesspa
dc.subject.keywordMyocyte fatty acid binding proteineng
dc.subject.keywordTroponineng
dc.subject.keywordAcute coronary syndromeeng
dc.titleRendimiento de la proteína ligadora de ácidos grasos del miocito para el diagnóstico de infarto de miocardiospa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
CardioDetect final.pdf
Tamaño:
466.18 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Especialización en Cardiología