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BACH2: A marker of DNA damage and ageing

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dc.creatorUittenboogaard, L.M.spa
dc.creatorPayan-Gomez, Cesarspa
dc.creatorPothof, J.spa
dc.creatorvan IJcken, W.spa
dc.creatorMastroberardino, P.G.spa
dc.creatorvan der Pluijm, I.spa
dc.creatorHoeijmakers, J.H.J.spa
dc.creatorTresini, M.spa
dc.date.accessioned2020-05-26T00:06:11Z
dc.date.available2020-05-26T00:06:11Z
dc.date.created2013spa
dc.description.abstractDNA damage and ageing share expression changes involving alterations in many aspects of metabolism, suppression of growth and upregulation of defence and genome maintenance systems. 'Omics' technologies have permitted large-scale parallel measurements covering global cellular constituents and aided the identification of specific response pathways that change during ageing and after DNA damage. We have set out to identify genes with highly conserved response patterns through meta-analysis of mRNA expression datasets collected during natural ageing and accelerated ageing caused by a Transcription-Coupled Nucleotide Excision Repair (TC-NER) defect in a diverse set of organs and tissues in mice, and from in vitro UV-induced DNA damage in a variety of murine cells. The identified set of genes that show similar expression patterns in response to organ ageing (accelerated and normal), and endogenously and exogenously induced DNA damage, consists of genes involved in anti-oxidant systems and includes the transcription factor Bach2 as one of the most consistent markers. BACH2 was originally identified as a partner of the small Maf proteins and antagonist of the NRF2 anti-oxidant defence pathway and has been implicated in B-cell differentiation and immune system homeostasis. Although BACH2 has never before been associated with UV-induced damage or ageing, it shows a strong downregulation in both conditions. We have characterized the dynamics of Bach2 expression in response to DNA damage and show that it is a highly sensitive responder to transcription-blocking DNA lesions. Gene expression profiling using Affymetrix microarray analysis after siRNA-mediated silencing of Bach2 identified cell cycle and transcription regulation as the most significantly altered processes consistent with a function as transcription factor affecting proliferation. © 2013 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.dnarep.2013.08.016
dc.identifier.issn15687864
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23864
dc.language.isoengspa
dc.relation.citationEndPage992
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage982
dc.relation.citationTitleDNA Repair
dc.relation.citationVolumeVol. 12
dc.relation.ispartofDNA Repair, ISSN:15687864, Vol.12, No.11 (2013); pp. 982-992spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84887170294&doi=10.1016%2fj.dnarep.2013.08.016&partnerID=40&md5=2d55ddff624e898c98c148e8695cace3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBiological markerspa
dc.subject.keywordionizingeng
dc.subject.keywordMessenger rnaspa
dc.subject.keywordanimaleng
dc.subject.keywordProtein v mafspa
dc.subject.keywordTranscription factorspa
dc.subject.keywordTranscription factor bach2spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAgingspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordArticlespa
dc.subject.keywordDna damagespa
dc.subject.keywordDown regulationspa
dc.subject.keywordExcision repairspa
dc.subject.keywordGene expression profilingspa
dc.subject.keywordGene identificationspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordImmune systemspa
dc.subject.keywordMicroarray analysisspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordTranscription regulationspa
dc.subject.keywordUltraviolet radiationspa
dc.subject.keywordMurinaespa
dc.subject.keywordMusspa
dc.subject.keywordAgeingspa
dc.subject.keywordBach2spa
dc.subject.keywordDna damagespa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordNrf2spa
dc.subject.keywordAgingspa
dc.subject.keywordAnimalsspa
dc.subject.keywordBasic-leucine zipper transcription factorsspa
dc.subject.keywordBiological markersspa
dc.subject.keywordCell survivalspa
dc.subject.keywordDna damagespa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordHek293 cellsspa
dc.subject.keywordHumansspa
dc.subject.keywordMicespa
dc.subject.keywordModelseng
dc.subject.keywordNih 3t3 cellsspa
dc.subject.keywordOligonucleotide array sequence analysisspa
dc.subject.keywordRadiationeng
dc.subject.keywordUltraviolet raysspa
dc.subject.keywordAgeingspa
dc.subject.keywordBach2spa
dc.subject.keywordDna damagespa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordNrf2spa
dc.titleBACH2: A marker of DNA damage and ageingspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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