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Intraspecific genomic divergence and minor structural variations in leishmania (Viannia) panamensis

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dc.creatorPatino, Luz H.spa
dc.creatorMuñoz, Marinaspa
dc.creatorMuskus, Carlosspa
dc.creatorMéndez-Sarmiento, Claudia
dc.creatorRamírez, Juan David
dc.date.accessioned2020-05-26T00:09:13Z
dc.date.available2020-05-26T00:09:13Z
dc.date.created2020spa
dc.description.abstractLeishmania (Viannia) panamensis is one of the most important Leishmania species associated with cutaneous leishmaniasis (CL) in Latin America. Despite its wide geographic distribution and pathogenic potential in humans and animals, the genomic variability of this species is low compared with other Leishmania species circulating in the same geographical area. No studies have reported a detailed analysis of the whole genome of L. panamensis from clinical isolates using DNA highthroughput sequencing to clarify its intraspecific genomic variability or plausible divergence. Therefore, this study aimed to evaluate the intraspecific genomic variability of L. panamensis from Colombia and Panama. A total of 22 genomes were analyzed, 19 from Colombian patients with CL and three genomes from Panama obtained from public databases. The phylogenomic analysis revealed the potential existence of three well-supported clades as evidence of intraspecific divergence. Additionally, the whole-genome analysis showed low structural variations in terms of ploidy, copy number variations, and single-nucleotide polymorphisms (SNPs). SNPs shared among all clades were identified, revealing their importance in different biological processes of L. panamensis. The findings not only expand our knowledge of intraspecific genomic variability of one of the most important Leishmania species in South America but also highlights the possible existence of different clades/lineages/subpopulations across a geographic scale. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/genes11030252
dc.identifier.issn20734425
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24145
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 3
dc.relation.citationTitleGenes
dc.relation.citationVolumeVol. 11
dc.relation.ispartofGenes, ISSN:20734425, Vol.11, No.3 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85080959829&doi=10.3390%2fgenes11030252&partnerID=40&md5=148432dcc15dd175feb88e8cf39fd7d4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordCopy number variationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGenomespa
dc.subject.keywordGenomicsspa
dc.subject.keywordLeishmania panamensisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhylogenomicsspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPloidyspa
dc.subject.keywordSanger sequencingspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordCopy number variationsspa
dc.subject.keywordCutaneous leishmaniasisspa
dc.subject.keywordDNA-seqspa
dc.subject.keywordGenomic variabilityspa
dc.subject.keywordLeishmania panamensisspa
dc.subject.keywordPhylogenetic analysisspa
dc.subject.keywordSingle-nucleotide polymorphismsspa
dc.titleIntraspecific genomic divergence and minor structural variations in leishmania (Viannia) panamensisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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