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Prevalence of non-responders for blood pressure and cardiometabolic risk factors among prehypertensive women after long-term high-intensity interval training

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dc.creatorÁlvarez, Cristianspa
dc.creatorRamírez-Campillo, Rodrigospa
dc.creatorCristi-Montero, Carlosspa
dc.creatorRamírez-Vélez, Robinsonspa
dc.creatorIzquierdo, Mikelspa
dc.date.accessioned2020-05-26T00:08:38Z
dc.date.available2020-05-26T00:08:38Z
dc.date.created2018spa
dc.description.abstractBackground: Exercise is known to improve cardiometabolic outcomes; however, results are typically reported as mean values, and there is wide interindividual variability in terms of response that has not been explored in populations at risk for hypertension. Our aim was to investigate both the effects on and the prevalence of non-responders (NRs) for decreasing blood pressure (BP) and other risk factors among prehypertensive women after long-term high-intensity interval training (HIIT). A secondary aim was to report potential variables that can predict decreases in BP after HIIT. Methods: Sedentary overweight/obese women (age 35.9 ± 5.4 year; body mass index [BMI] 30.9 ± 6.2 kg/m2) were assigned to a prehypertensive (PreHTN; N = 44) or normotensive (NT; N = 40) group according to their ambulatory BP at baseline. Subjects underwent a thrice-weekly 16-week HIIT program (7-10 × 1 min exercise with 2 min of rest). Training-induced changes in body composition and cardiovascular, metabolic, strength, and endurance performance markers were measured, and the prevalence of NRs was reported as a percentage. All outcomes were analyzed by multivariable regression. Results: Statistically significant (P and lt; 0.05) decreases in systolic BP (SBP) were detected in the PreHTN group (? -8 mmHg) compared with baseline, whereas the NT group (? + 3 mmHg) showed a non-significant increase in SBP. Diastolic BP (DBP) was significantly decreased in the PreHTN group (? -5.8 mmHg) and non-significantly decreased (? -2 mmHg) in the NT group. Also, there were significant differences (P and lt; 0.0001) in the prevalence of NRs based on SBP between the PreHTN and NT groups (11.4 vs. 68.8%), but similar prevalence of NRs based on DBP. SBP alone was a powerful predictive factor for a beneficial SBP reduction, explaining 51.2% of the results, which was similar to other more complex models tested. Conclusion: The prevalence of NRs based on SBP and DBP was different between prehypertensive and normotensive subjects after 16 weeks of HIIT. Other comorbidities such as body composition and metabolic outcomes showed almost similar modifications between prehypertensive and normotensive subjects, being the most basic predictive factor for BP reduction baseline SBP, which we refer to as 'BP health status' (51.2%). This improvement in BP was accompanied by other known improvements of HIIT on body composition, metabolic and endurance performance in both study cohorts. © 2007 - 2018 Frontiers Media S.A.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.01443
dc.identifier.issn1664042X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24100
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationIssueNo. OCT
dc.relation.citationTitleFrontiers in Physiology
dc.relation.citationVolumeVol. 9
dc.relation.ispartofFrontiers in Physiology, ISSN:1664042X, Vol.9, No.OCT (2018)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056122596&doi=10.3389%2ffphys.2018.01443&partnerID=40&md5=924f1421864a67d3ebc5e5e28e40348fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood pressurespa
dc.subject.keywordBlood pressure regulationspa
dc.subject.keywordBody compositionspa
dc.subject.keywordCardiometabolic riskspa
dc.subject.keywordClinical articlespa
dc.subject.keywordClinical trialspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordComorbidityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiastolic blood pressurespa
dc.subject.keywordEndurancespa
dc.subject.keywordFemalespa
dc.subject.keywordGlucose blood levelspa
dc.subject.keywordHigh density lipoprotein cholesterol levelspa
dc.subject.keywordHigh intensity interval trainingspa
dc.subject.keywordHumanspa
dc.subject.keywordIntervention studyspa
dc.subject.keywordLong term carespa
dc.subject.keywordLow density lipoprotein cholesterol levelspa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPrehypertensionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorspa
dc.subject.keywordRisk reductionspa
dc.subject.keywordSkinfold thicknessspa
dc.subject.keywordStrengthspa
dc.subject.keywordSystolic blood pressurespa
dc.subject.keywordTherapy effectspa
dc.subject.keywordTreatment responsespa
dc.subject.keywordTriacylglycerol blood levelspa
dc.subject.keywordWaist circumferencespa
dc.subject.keywordHigh-intensity interval trainingspa
dc.subject.keywordNon-respondersspa
dc.subject.keywordPrehypertensionspa
dc.subject.keywordRespondersspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSystolic blood pressurespa
dc.subject.keywordWomenspa
dc.titlePrevalence of non-responders for blood pressure and cardiometabolic risk factors among prehypertensive women after long-term high-intensity interval trainingspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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