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Supervivencia en una cohorte de pacientes con adenocarcinoma gástrico resecable, Bogotá, 2005-2018

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dc.contributor.advisorZuluaga Cristancho, Eduardo Alirio
dc.contributor.advisorBuitrago Medina, Daniel Alejandro
dc.creatorZuluaga Liberato, Andrea Marcela
dc.creatorGuavita Navarro, Diana Katherine
dc.creator.degreeEspecialista en Medicina Internaspa
dc.creator.degreetypeFull timespa
dc.date.accessioned2019-02-18T22:42:09Z
dc.date.available2019-02-18T22:42:09Z
dc.date.created2019-02-06
dc.date.issued2019
dc.descriptionIntroducción: El cáncer gástrico es la quinta malignidad más común en el mundo, y la tercera causa de muerte por cáncer en el mundo. Es importante conocer en Colombia la supervivencia global y libre de enfermedad a 5 años, así como factores pronósticos. Métodos: Se revisaron 106 historias clínicas de un centro oncológico de Bogotá, Colombia de Enero de 2005 a Junio de 2018, se realizó un análisis de supervivencia con método de Kaplan Meier, prueba Log-rank y Regresión de COX. Resultados: La mediana de seguimiento fue 21 meses, la mayoría de pacientes fueron hombres (53.7%), con diagnóstico temprano en 63.2% (estadios 0, I y II), mediana de edad al diagnóstico de 57.8 años, cero ganglios comprometidos (44.3%), tipo histológico intestinal (45.3%) y pobre grado de diferenciación tumoral (57.5%). La supervivencia libre de enfermedad a 1, 3 y 5 años fue de 84%, 53% y 46.3%; y la supervivencia global de 94.1%, 82% y 69.4%. Como factor pronóstico, se encontró que el mayor número de ganglios comprometidos al diagnóstico disminuye la supervivencia libre de enfermedad, (1-2 ganglios: HR 6.46 IC95%1.16-35.92; 3-6 ganglios: HR 4.44 IC95% 1.25-15.77; y ≥7 ganglios: HR 10.84 IC95% 3.57-32.9) y disminuye la supervivencia global (≥7 ganglios: HR 6.56 IC95% 1.69-25.37). Conclusión: La supervivencia global y libre de enfermedad fue mayor que la descrita en la literatura; se encontró el número de ganglios comprometidos al diagnóstico como factor de riesgo para mortalidad y recaídas más tempranas.spa
dc.description.abstractIntroduction: Gastric cancer is the fifth most common malignancy in the world, and the third cause of cancer death in the world. It is important to know in Colombia the global survival and the disease-free survival at 5 years, as well as prognostic factors. Methods: We reviewed 106 medical records of a cancer center in Bogotá, Colombia from January 2005 to June 2018. We performed a survival analysis using the Kaplan Meier method, Log-rank test and COX regression. Results: The median follow-up was 21 months, the majority of patients were males (53.7%), have early diagnosis in 63.2% (stages 0, I and II), median age of diagnosis of 57.8 years, have none lymph node involved (44.3%), intestinal histological type (45.3%) and poorly differentiated (57.5%). Disease-free survival at 1, 3 and 5 years was 84%, 53% and 46.3%; and overall survival was 94.1%, 82% and 69.4%. The number of lymph nodes involved in the diagnosis of disease-free survival was found as a prognostic factor (1-2 lymph nodes: HR 6.46 IC95% 1.16-35.92, 3-6 nodes: HR 4.44 IC95% 1.25-15.77, and ≥7 nodes: HR 10.84 IC95% 3.57-32.9) and for overall survival (≥7 nodes: HR 6.56 IC95% 1.69-25.37). Conclusion: The overall survival and disease free survival was greater than the described in the literature, finding as a risk factor for disease-free survival and overall survival, the number of lymph nodes involved at diagnosis.spa
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dc.identifier.doihttps://doi.org/10.48713/10336_19102
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19102
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Medicina Internaspa
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dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectCáncer gástricospa
dc.subjectAnálisis de supervivenciaspa
dc.subjectRecaídaspa
dc.subjectMortalidadspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordGastric cancerspa
dc.subject.keywordsurvival analysisspa
dc.subject.keywordrelapsespa
dc.subject.keywordmortalityspa
dc.subject.lembEnfermedades del estómagospa
dc.subject.lembNeoplasias gástricasspa
dc.titleSupervivencia en una cohorte de pacientes con adenocarcinoma gástrico resecable, Bogotá, 2005-2018spa
dc.typemasterThesiseng
dc.type.documentTrabajo de gradospa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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