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Autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA) - Animal models as a proof of concept

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dc.creatorCruz-Tapias P.spa
dc.creatorAgmon-Levin N.spa
dc.creatorIsraeli E.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorShoenfeld Y.spa
dc.date.accessioned2020-05-26T00:05:43Z
dc.date.available2020-05-26T00:05:43Z
dc.date.created2013spa
dc.description.abstractASIA syndrome, 'Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants' includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants. © 2013 Bentham Science Publishers.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/09298673113209990253
dc.identifier.issn9298673
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23818
dc.language.isoengspa
dc.relation.citationEndPage4036
dc.relation.citationIssueNo. 32
dc.relation.citationStartPage4030
dc.relation.citationTitleCurrent Medicinal Chemistry
dc.relation.citationVolumeVol. 20
dc.relation.ispartofCurrent Medicinal Chemistry, ISSN:9298673, Vol.20, No.32 (2013); pp. 4030-4036spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84887885221&doi=10.2174%2f09298673113209990253&partnerID=40&md5=b773318c95cf28d431359c753b32b1c2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdjuvantspa
dc.subject.keywordpharmaceuticeng
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordanimaleng
dc.subject.keywordAluminum saltspa
dc.subject.keywordAvridinespa
dc.subject.keywordFreund adjuvantspa
dc.subject.keywordGlycerolspa
dc.subject.keywordIc 31spa
dc.subject.keywordLipopolysaccharidespa
dc.subject.keywordPeptidoglycanspa
dc.subject.keywordPristanespa
dc.subject.keywordQs 21spa
dc.subject.keywordSqualenespa
dc.subject.keywordTetanus toxoidspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordGranulomaspa
dc.subject.keywordGranulomatous inflammationspa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHumanspa
dc.subject.keywordLupus like syndromespa
dc.subject.keywordMyocarditisspa
dc.subject.keywordNeurotoxicityspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhysical chemistryspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSalmonspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordThyroid diseasespa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordDisease modelseng
dc.subject.keywordHumansspa
dc.subject.keywordImmune systemspa
dc.subject.keywordInflammationspa
dc.subject.keywordAdjuvantsspa
dc.subject.keywordAnimal modelsspa
dc.subject.keywordAsiaspa
dc.subject.keywordAuto-inflammatory syndromespa
dc.subject.keywordAutoimmune syndromespa
dc.titleAutoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA) - Animal models as a proof of conceptspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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