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Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

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dc.audienceComunidad Rosaristaspa
dc.creatorForero Rodríguez, Johanna
dc.creatorGarzón Ospina, Diego
dc.creatorPatarroyo, Manuel A.
dc.creator.googleForero Rodríguez, Johanna
dc.creator.googleGarzón Ospina, Diego
dc.creator.googlePatarroyo, Manuel A.
dc.date.accessioned2014-08-13T15:21:57Z
dc.date.available2014-08-13T15:21:57Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractBackground Plasmodium vivax is one of the five species causing malaria in human beings, affecting around 391 million people annually. The development of an anti-malarial vaccine has been proposed as an alternative for controlling this disease. However, its development has been hampered by allele-specific responses produced by the high genetic diversity shown by some parasite antigens. Evaluating these antigens’ genetic diversity is thus essential when designing a completely effective vaccine. Methods The gene sequences of Plasmodium vivax p12 (pv12) and p38 (pv38), obtained from field isolates in Colombia, were used for evaluating haplotype polymorphism and distribution by population genetics analysis. The evolutionary forces generating the variation pattern so observed were also determined. Results Both pv12 and pv38 were shown to have low genetic diversity. The neutral model for pv12 could not be discarded, whilst polymorphism in pv38 was maintained by balanced selection restricted to the gene’s 5′ region. Both encoded proteins seemed to have functional/structural constraints due to the presence of s48/45 domains, which were seen to be highly conserved.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:1475-2875
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8822
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 58
dc.relation.citationTitleMalaria Journal
dc.relation.citationVolumeVol. 13
dc.relation.ispartofMalaria Journal ISSN 1475-2875 V. 13 N. 58 2014spa
dc.relation.urihttp://www.malariajournal.com/content/pdf/1475-2875-13-58.pdf
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEnfermedades
dc.subject.decsPlasmodiumspa
dc.subject.decsMalariaspa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsInmunologíaspa
dc.titleLow genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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