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Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus

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dc.creatorMaiti, Amit K.spa
dc.creatorKim?Howard, Xanaspa
dc.creatorViswanathan, Parvathispa
dc.creatorGuillén, Lauraspa
dc.creatorRojas-Villarraga, Adriana
dc.creatorDeshmukh, Harshalspa
dc.creatorDireskeneli, Hanerspa
dc.creatorSaruhan?Direskeneli, Güherspa
dc.creatorCañas, Carlosspa
dc.creatorTobön, Gabriel J.spa
dc.creatorSawalha, Amr H.spa
dc.creatorCherñavsky, Alejandra C.spa
dc.creatorAnaya, Juan-Manuel
dc.creatorNath, Swapan K.spa
dc.date.accessioned2020-05-25T23:58:57Z
dc.date.available2020-05-25T23:58:57Z
dc.date.created2010spa
dc.description.abstractObjective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations. © 2010, American College of Rheumatology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/art.27222
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22955
dc.language.isoengspa
dc.relation.citationEndPage329
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage323
dc.relation.citationTitleArthritis and Rheumatism
dc.relation.citationVolumeVol. 62
dc.relation.ispartofArthritis and Rheumatism, Vol.62, No.2 (2010); pp. 323-329spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-75749113734&doi=10.1002%2fart.27222&partnerID=40&md5=caa944952a6229986fc509d1d96a8853spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordtype 1eng
dc.subject.keywordAllelespa
dc.subject.keywordArgentinaspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordBehcet diseasespa
dc.subject.keywordCase control studyspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordData analysisspa
dc.subject.keywordEnteritisspa
dc.subject.keywordEuropespa
dc.subject.keywordEvaluationspa
dc.subject.keywordEvidence based medicinespa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordStatistical significancespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTurkey (bird)spa
dc.subject.keywordUlcerative colitisspa
dc.subject.keywordArgentinaspa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordInterleukin-2spa
dc.subject.keywordInterleukinsspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordPhenotypespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordTurkeyspa
dc.titleConfirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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