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Primary Joint Arthroplasty Surgery: Is the Risk of Major Bleeding Higher in Elderly Patients? A Retrospective Cohort Study

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dc.creatorQuintero, Jorge I.spa
dc.creatorCárdenas, Laura L.spa
dc.creatorNavas, Mónicaspa
dc.creatorBautista, Maria P.spa
dc.creatorBonilla, Guillermo A.spa
dc.creatorLlinás, Adolfo M.spa
dc.creatorSurgery, Clinical Care Program in Joint Replacementspa
dc.date.accessioned2020-05-25T23:55:51Z
dc.date.available2020-05-25T23:55:51Z
dc.date.created2016spa
dc.description.abstractBackground Increased risk of bleeding after major orthopedic surgery (MOS) has been widely documented in general population. However, this complication has not been studied in elderly patients. The purpose of this study is to determine whether the risk of major bleeding after MOS is higher in elderly patients, compared with those operated at a younger age. Methods This retrospective cohort study included total hip and total knee arthroplasty patients operated during 5 consecutive years. The main outcome was the occurrence of major bleeding. Patients with other causes of bleeding were excluded. Relative risks (RRs) and confidence intervals (CIs) were calculated, and a multivariate analysis was performed. Results A total of 1048 patients were included, 56% of patients were hip arthroplasties. At the time of surgery, 553 (53%) patients were older than 70 years. Patients aged >70 years showed an increased risk of major bleeding (RR: 2.42 [95% CI: 1.54-3.81]). For hip arthroplasty, the RR of bleeding was 2.61 (95%CI: 1.50-4.53) and 2.25 (95% CI: 1.03-4.94) for knee arthroplasty. After multivariate analysis, age was found to be independently associated with higher risk of major bleeding. Conclusion According to European Medicines Agency criteria, patients aged ?70 years are at a higher risk of major bleeding after MOS, result of a higher frequency of blood transfusions in this group of patients. Standardized protocols for blood transfusion in these patients are still required. © 2016 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.arth.2016.03.025
dc.identifier.issn08835403
dc.identifier.issn15328406
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22238
dc.language.isoengspa
dc.publisherChurchill Livingstone Inc.spa
dc.relation.citationEndPage2268
dc.relation.citationIssueNo. 10
dc.relation.citationStartPage2264
dc.relation.citationTitleJournal of Arthroplasty
dc.relation.citationVolumeVol. 31
dc.relation.ispartofJournal of Arthroplasty, ISSN:08835403, 15328406, Vol.31, No.10 (2016); pp. 2264-2268spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84975744157&doi=10.1016%2fj.arth.2016.03.025&partnerID=40&md5=df4196f7619ccd2730381b4042433327spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDabigatranspa
dc.subject.keywordreplacementeng
dc.subject.keywordkneeeng
dc.subject.keywordRivaroxabanspa
dc.subject.keywordAnticoagulant agentspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordHigh risk patientspa
dc.subject.keywordHip arthroplastyspa
dc.subject.keywordHip diseasespa
dc.subject.keywordHumanspa
dc.subject.keywordKnee diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMajor surgeryspa
dc.subject.keywordMalespa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPatient safetyspa
dc.subject.keywordPostoperative hemorrhagespa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSurgical patientspa
dc.subject.keywordSurgical riskspa
dc.subject.keywordTotal knee arthroplastyspa
dc.subject.keywordTreatment responsespa
dc.subject.keywordAdverse effectsspa
dc.subject.keywordAgespa
dc.subject.keywordBlood transfusionspa
dc.subject.keywordChemically inducedspa
dc.subject.keywordColombiaspa
dc.subject.keywordComparative studyspa
dc.subject.keywordHemorrhagespa
dc.subject.keywordHip replacementspa
dc.subject.keywordKnee replacementspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOrthopedic surgeryspa
dc.subject.keywordPostoperative complicationsspa
dc.subject.keywordRisk factorspa
dc.subject.keywordVenous thromboembolismspa
dc.subject.keywordVery elderlyspa
dc.subject.keywordAge factorsspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordAnticoagulantsspa
dc.subject.keywordArthroplastyeng
dc.subject.keywordArthroplastyeng
dc.subject.keywordBlood transfusionspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordHemorrhagespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOrthopedic proceduresspa
dc.subject.keywordPostoperative complicationsspa
dc.subject.keywordRetrospective studiesspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordVenous thromboembolismspa
dc.subject.keywordAgedspa
dc.subject.keywordAnticoagulantsspa
dc.subject.keywordArthroplastyspa
dc.subject.keywordHipspa
dc.subject.keywordKneespa
dc.subject.keywordPostoperative hemorrhagespa
dc.titlePrimary Joint Arthroplasty Surgery: Is the Risk of Major Bleeding Higher in Elderly Patients? A Retrospective Cohort Studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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