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Role of vasoactive substances in the segmentary vasomotor response following spinal cord stimulation: an experimental study

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dc.creatorSánchez-Ledesma, M.J.spa
dc.creatorGarcia-March, G.spa
dc.creatorGonçalves, J.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorSilva, I.spa
dc.creatorGonzalez-Buitrago, J.M.spa
dc.creatorNavajo, J.A.spa
dc.creatorBroseta, J.spa
dc.date.accessioned2020-08-19T14:40:31Z
dc.date.available2020-08-19T14:40:31Z
dc.date.created1990-11-28spa
dc.description.abstractIt is presumed today that spinal cord stimulation induces local delivery of vasoactive substances, such as prostacyclins, histamine, substance P, and vasoactive neuropeptides, in the perivascular environment and the vascular wall to mediate the segmental vasodilator response. To investigate this mechanism, 9 dogs were subjected to low thoracic spinal cord stimulation. Venous and arterial blood samples from the paresthesic area in the lower limbs were obtained before and 120 min after stimulation to measure changes in the plasma concentration of vasoactive intestinal peptide, substance P, and histamine. The results were compared with those obtained from vessels of the upper limbs. Blood flow changes following stimulation were recorded by electromagnetic flowmeters. Local arterial vasoactive intestinal peptide showed a mean increase of 33% after 60 min of stimulation. Changes concerning substance P were inconclusive. Local arterial and venous histamine concentrations increased 26 and 29%, respectively, after 60 min of stimulation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1159/000100216
dc.identifier.issnISSN: 1011-6125
dc.identifier.issnEISSN: 1423-0372
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26915
dc.language.isoengspa
dc.publisherKarger AGspa
dc.relation.citationEndPage231
dc.relation.citationIssueNo. 1-8
dc.relation.citationStartPage224
dc.relation.citationTitleStereotactic and Functional Neurosurgery
dc.relation.citationVolumeVol. 54-55
dc.relation.ispartofStereotactic and Functional Neurosurgery, ISSN: 1011-6125;EISSN: 1423-0372, Vol.54-55, No.1-8 (1990); pp. 224-231spa
dc.relation.urihttps://www.karger.com/Article/Abstract/100216spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceStereotactic and Functional Neurosurgeryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSpinal cord stimulationspa
dc.subject.keywordHistaminespa
dc.subject.keywordSubstance Pspa
dc.titleRole of vasoactive substances in the segmentary vasomotor response following spinal cord stimulation: an experimental studyspa
dc.title.TranslatedTitlePapel de las sustancias vasoactivas en la respuesta vasomotora segmentaria tras la estimulación de la médula espinal: un estudio experimentalspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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