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Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice

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dc.creatorJongbloed, Franny
dc.creatorde Bruin, Ron W. F.
dc.creatorPennings, Jeroen L. A.
dc.creatorPayan-Gomez, Cesar
dc.creatorEngel, Sandra van den
dc.creatorOostrom, Conny T. van
dc.creatorde Bruin, Alain
dc.creatorHoeijmakers, Jan H. J.
dc.creatorSteeg, Harry van
dc.creatorIJzermans, Jan N. M.
dc.creatorDollé, Martijn E. T.
dc.creator.googleJongbloed, Frannyspa
dc.creator.googlede Bruin, Ron W. F.spa
dc.creator.googlePennings, Jeroen L. A.spa
dc.creator.googlePayán-Gómez, Césarspa
dc.creator.googleEngel, Sandra van denspa
dc.creator.googleOostrom, Conny T. vanspa
dc.creator.googlede Bruin, Alainspa
dc.creator.googleHoeijmakers, Jan H. J.spa
dc.creator.googleSteeg, Harry vanspa
dc.creator.googleIJzermans, Jan N. M.spa
dc.creator.googleDollé, Martijn E. T.spa
dc.date.accessioned2018-11-19T15:04:32Z
dc.date.available2018-11-19T15:04:32Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractIschemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that preoperative fasting in young-lean male mice protects against IRI. Since patients are generally of older age with morbidities possibly leading to a different response to fasting, we investigated the effects of preoperative fasting on renal IRI in aged-overweight male and female mice. Male and female F1-FVB/C57BL6-hybrid mice, average age 73 weeks weighing 47.2 grams, were randomized to preoperative ad libitum feeding or 3 days fasting, followed by renal IRI. Body weight, kidney function and survival of the animals were monitored until day 28 postoperatively. Kidney histopathology was scored for all animals and gene expression profiles after fasting were analyzed in kidneys of young and aged male mice. Preoperative fasting significantly improved survival after renal IRI in both sexes compared with normal fed mice. Fasted groups had a better kidney function shown by lower serum urea levels after renal IRI. Histopathology showed less acute tubular necrosis and more regeneration in kidneys from fasted mice. A mRNA analysis indicated the involvement of metabolic processes including fatty acid oxidation and retinol metabolism, and the NRF2-mediated stress response. Similar to young-lean, healthy male mice, preoperative fasting protects against renal IRI in aged-overweight mice of both genders. These findings suggest a general protective response of fasting against renal IRI regardless of age, gender, body weight and genetic background. Therefore, fasting could be a non-invasive intervention inducing increased oxidative stress resistance in older and overweight patients as well. © 2014 Jongbloed et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0100853
dc.identifier.issnISSN 1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18701
dc.language.isoengspa
dc.relation.citationIssueNo. 6
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 9/No. 6 (2014)spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100853&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationTonelli, M., Wiebe, N., Knoll, G., Bello, A., Browne, S., Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes (2011) Am J Transplant, 11, pp. 2093-2109spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectGlutatión transferasa A2spa
dc.subjectMensajero RNAspa
dc.subjectRetinolspa
dc.subjectFactor de transcripción Nrf2spa
dc.subjectDistribución de edadspa
dc.subjectEnvejecidospa
dc.subjectExperimento con animalesspa
dc.subjectModelo animalspa
dc.subjectTejido animalspa
dc.subjectPeso corporalspa
dc.subjectEstudio controladospa
dc.subjectCyp4A14 gen Dspa
dc.subjectRestricción de la dietaspa
dc.subjectOxidación de ácidos grasosspa
dc.subjectGenspa
dc.subjectPerfiles de expresión génicaspa
dc.subjectGen Gsta2spa
dc.subjectHistopatologíaspa
dc.subjectFunción del riñónspa
dc.subjectLesión renalspa
dc.subjectIsquemia renalspa
dc.subjectNecrosis del túbulo renalspa
dc.subjectSecuencia de nucleótidosspa
dc.subjectObesidadspa
dc.subjectPeríodo preoperatoriospa
dc.subjectProtección Renalspa
dc.subjectLesión por reperfusiónspa
dc.subjectGen Sc4Molspa
dc.subjectEstrésspa
dc.subjectTasa de supervivenciaspa
dc.subjectRegeneración de Tejidosspa
dc.subjectNivel de urea en sangrespa
dc.subjectMetabolismo de las vitaminasspa
dc.subjectEfectos adversosspa
dc.subjectRatón C57Blspa
dc.subjectTrasplante de riñónspa
dc.subjectMetabolismospa
dc.subjectObesidadspa
dc.subjectEstrés oxidativospa
dc.subjectPatologíaspa
dc.subjectLesión por reperfusiónspa
dc.subjectNivel de sangre de nitrógeno ureicospa
dc.subjectFactores de edadspa
dc.subjectNitrógeno ureico en sangrespa
dc.subjectRedes y vías metabólicasspa
dc.subjectRatones endogámicos C57Blspa
dc.subjectExceso de pesospa
dc.subjectEstrés oxidativospa
dc.subjectLesión por reperfusiónspa
dc.subject.keywordReperfusion Injuryspa
dc.subject.keywordOxidative Stressspa
dc.subject.keywordMice, Inbred C57Blspa
dc.subject.keywordOverweighteng
dc.subject.keywordBlood Urea Nitrogeneng
dc.subject.keywordMetabolic Networks And Pathwayseng
dc.subject.keywordAge Factorseng
dc.subject.keywordUrea Nitrogen Blood Leveleng
dc.subject.keywordReperfusion Injuryeng
dc.subject.keywordPathologyeng
dc.subject.keywordOxidative Stresseng
dc.subject.keywordObesityeng
dc.subject.keywordKidney Transplantationeng
dc.subject.keywordMetabolismeng
dc.subject.keywordC57Bl Mouseeng
dc.subject.keywordAdverse Effectseng
dc.subject.keywordVitamin Metabolismeng
dc.subject.keywordUrea Blood Leveleng
dc.subject.keywordTissue Regenerationeng
dc.subject.keywordSurvival Rateeng
dc.subject.keywordStresseng
dc.subject.keywordSc4Mol Geneeng
dc.subject.keywordReperfusion Injuryeng
dc.subject.keywordPreoperative Periodeng
dc.subject.keywordRenal Protectioneng
dc.subject.keywordObesityeng
dc.subject.keywordNucleotide Sequeneeng
dc.subject.keywordKidney Tubule Necrosiseng
dc.subject.keywordKidney Ischemiaeng
dc.subject.keywordKidney Injuryeng
dc.subject.keywordKidney Functioneng
dc.subject.keywordHistopathologyeng
dc.subject.keywordGsta2 Geneeng
dc.subject.keywordGene Expression Profilingeng
dc.subject.keywordGeneeng
dc.subject.keywordFatty Acid Oxidationeng
dc.subject.keywordDiet Restrictioneng
dc.subject.keywordCyp4A14 Dgeneeng
dc.subject.keywordControlled Studyeng
dc.subject.keywordBody Weighteng
dc.subject.keywordAnimal Tissueeng
dc.subject.keywordAnimal Modeleng
dc.subject.keywordAnimal Experimenteng
dc.subject.keywordAgedeng
dc.subject.keywordAge Distributioneng
dc.subject.keywordUreaeng
dc.subject.keywordTranscription Factor Nrf2eng
dc.subject.keywordMessenger Rnaeng
dc.subject.keywordGlutathione Transferase A2eng
dc.subject.lembTrasplante de riñonspa
dc.subject.lembIsquemiaspa
dc.subject.lembReperfusiónspa
dc.titlePreoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight micespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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