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Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi

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dc.creatorMuñoz, José F.
dc.creatorMcEwen, Juan G.
dc.creatorClay, Oliver
dc.creatorCuomo, Christina A.
dc.creator.googleMuñoz, J.F.spa
dc.creator.googleMcEwen, J.G.spa
dc.creator.googleClay, O.K.spa
dc.creator.googleCuomo, C.A.spa
dc.date.accessioned2019-08-08T14:53:34Z
dc.date.available2019-08-08T14:53:34Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractDimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and two basal branching, non-pathogenic species in the Ajellomycetaceae, Helicocarpus griseus and Polytolypa hystricis. We found that gene families related to plant degradation, secondary metabolites synthesis, and amino acid and lipid metabolism are retained in H. griseus and P. hystricis. While genes involved in the virulence of dimorphic pathogenic fungi are conserved in saprophytes, changes in the copy number of proteases, kinases and transcription factors in systemic dimorphic relative to non-dimorphic species may have aided the evolution of specialized gene regulatory programs to rapidly adapt to higher temperatures and new nutritional environments. Notably, both of the basal branching, non-pathogenic species appear homothallic, with both mating type locus idiomorphs fused at a single locus, whereas all related pathogenic species are heterothallic. These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches. © 2018 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1038/s41598-018-22816-6
dc.identifier.issn2045-2322
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/20070
dc.language.isoengspa
dc.relation.citationTitleScientific Reports
dc.relation.citationVolumeVol. 8
dc.relation.ispartofScientific Reports, ISSN:2045-2322, Vol. 8 (2018)spa
dc.relation.urihttps://www.nature.com/articles/s41598-018-22816-6spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationKlein, B.S., Tebbets, B., Dimorphism and virulence in fungi (2007) Curr Opin Microbiol, 10, pp. 314-319spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectFungal Pathogensspa
dc.subjectNonpathogenic Speciespa
dc.subjectBasal Branchingspa
dc.subjectBranching Nonpathogenicspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembHongos patógenosspa
dc.subject.lembEspecie no patógenospa
dc.subject.lembRamificación basalspa
dc.subject.lembRamificación no patógenasspa
dc.titleGenome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungispa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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