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The I?BL gene polymorphism influences risk of acquiring systemic lupus erythematosus and Sjögren's syndrome

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dc.creatorCastiblanco, Johnspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:10:14Z
dc.date.available2020-05-26T00:10:14Z
dc.date.created2008spa
dc.description.abstractThe human inhibitory ?B-like gene (I?BL) maps to a chromosomal region ?25 kb telomeric of the TNF gene at 6p21.3. I?BL encodes a protein related to I?B? that may interact with members of the NF-?B/Rel family. We evaluated the role of I?BL gene polymorphism in systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Genomic DNA isolated from individuals with SLE (n = 134), pSS (n = 67) and from individuals matched for age, sex, and ethnicity (n = 423) was genotyped for ?-473, -62T/A and +738T/C polymorphisms. The -62A allele was associated with a decrease in the risk of acquiring SLE in a recessive manner; whereas the +738C allele was associated with a more than twofold and threefold increase in the risk of SLE and pSS respectively, relative to the +738T allele. Four haplotypes were observed for the I?BL polymorphisms. Haplotype -62A+738T (AT) was associated with a 37% decrease in the risk of SLE, whereas AC tended to increase the risk of developing pSS. Using previously reported TNF data, an almost twofold increased in the risk of SLE was observed between haplotypes IKBL-62T+738T/TNF-308G-238G (TTGG) and TTAG because of linkage disequilibrium between IKBL-62T and TNF-308A. Our findings indicate that the I?BL gene influences the risk of developing SLE and pSS. © 2008 American Society for Histocompatibility and Immunogenetics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2007.11.008
dc.identifier.issn1988859
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24219
dc.language.isoengspa
dc.relation.citationEndPage51
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage45
dc.relation.citationTitleHuman Immunology
dc.relation.citationVolumeVol. 69
dc.relation.ispartofHuman Immunology, ISSN:1988859, Vol.69, No.1 (2008); pp. 45-51spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-39549111010&doi=10.1016%2fj.humimm.2007.11.008&partnerID=40&md5=1d79fd42c9e672e6516d45f8fcc6d6c3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordI kappa Bspa
dc.subject.keywordSystemiceng
dc.subject.keywordGeneticeng
dc.subject.keywordhumaneng
dc.subject.keywordHLA antigen class 2spa
dc.subject.keywordNFKBIL1 proteineng
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDNA isolationspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSchool childspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordChildspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene linkage disequilibriumspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordChildspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHistocompatibility Antigens Class IIspa
dc.subject.keywordHumansspa
dc.subject.keywordLinkage Disequilibriumspa
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordTumor Necrosis Factor-alphaspa
dc.subject.keywordI?blspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTNFspa
dc.titleThe I?BL gene polymorphism influences risk of acquiring systemic lupus erythematosus and Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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