Ítem
Solo Metadatos
Autoimmunity and tuberculosis. Opposite association with TNF polymorphism
| dc.creator | Correa, Paula A. | spa |
| dc.creator | Gómez, Luis M. | spa |
| dc.creator | Cadena, Jose | spa |
| dc.creator | Anaya, Juan-Manuel | spa |
| dc.date.accessioned | 2020-08-06T16:20:32Z | |
| dc.date.available | 2020-08-06T16:20:32Z | |
| dc.date.created | 2005 | spa |
| dc.description.abstract | Objective. To examine the influence of the –308 and –238 single nucleotide polymorphisms (SNP) of tumor necrosis factor-? gene (TNF) on patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren’s syndrome (SS), and tuberculosis (TB). Methods. Genomic DNA from patients with RA (n = 165), SLE (n = 100), primary SS (n = 67), and TB (n = 135) and ethnically matched controls (n = 430) was genotyped for TNF –308 and –238 SNP by PCR-RFLP. Results. TNF –308A allele was associated with RA (odds ratio, OR 1.8, p = 0.002), SLE (OR 2.6, p < 0.0001), and primary SS (OR 2.9, p < 0.0001). TNF –308G was associated with TB (OR 1.8, p = 0.02). The –308 GG genotype was protective for autoimmunity (p < 0.003). TNF –238A allele was protective for autoimmunity but represented a susceptibility factor for TB (OR 2.2, p < 0.0001). Haplotype –308A–238G was a protective factor against TB, whereas it carried susceptibility for RA, SLE, and primary SS (p < 0.0001). Conclusion. The results show an opposite association of TNF polymorphism with autoimmunity and TB, and suggest the existence of heterozygote advantage, sustaining the hypothesis that autoimmune diseases are a consequence of natural selection for enhanced TB resistance. Data also provide genetic evidence supporting the common variants/multiple disease hypothesis, which emphasizes that many disease genes may not be disease-specific, and that similar immunogenetic mechanisms underlie autoimmune diseases. (J Rheumatol 2005;32:219–24) | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.issn | ISSN: 0315-162X | |
| dc.identifier.issn | EISSN: 1499-2752 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/26049 | |
| dc.language.iso | eng | spa |
| dc.publisher | Canadian Rheumatology Association | spa |
| dc.relation.citationEndPage | 224 | |
| dc.relation.citationIssue | No. 2 | |
| dc.relation.citationStartPage | 219 | |
| dc.relation.citationTitle | Journal of Rheumatology | |
| dc.relation.citationVolume | Vol. 32 | |
| dc.relation.ispartof | The Journal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.32, No.2 (february, 2005) pp.219-224 | spa |
| dc.relation.uri | https://www.jrheum.org/content/jrheum/32/2/219.full.pdf | spa |
| dc.rights.accesRights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.acceso | Restringido (Acceso a grupos específicos) | spa |
| dc.source | Journal of Rheumatology | spa |
| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject.keyword | Tumor necrosis factor | spa |
| dc.subject.keyword | Rheumatoid arthritis | spa |
| dc.subject.keyword | Tuberculosis systemic lupus erythematosus | spa |
| dc.subject.keyword | Sjögren’s Syndrome | spa |
| dc.subject.keyword | Autoimmunity | spa |
| dc.title | Autoimmunity and tuberculosis. Opposite association with TNF polymorphism | spa |
| dc.title.TranslatedTitle | Autoinmunidad y tuberculosis. Asociación opuesta con polimorfismo TNF | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
