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Gauche+ side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine

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dc.creatorBermudez, Adriana
dc.creatorCalderon, Dayanaspa
dc.creatorMoreno-Vranich, Armandospa
dc.creatorAlmonacid, Hanniaspa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorPoloche, Andrésspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:02:14Z
dc.date.available2020-05-26T00:02:14Z
dc.date.created2014spa
dc.description.abstractTopological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed a polyproline II-like (PPIIL) structure when mixed. Here we show that amino acid side-chains located in peptide binding region (PBR) positions p3 and p7 displayed specific electron charges and side-chain gauche+ orientation for interacting with the TCR. Based on the above, and previously described physicochemical principles, non-interfering, long-lasting, full protection-inducing, multi-epitope, multistage, minimal subunit-based chemically synthesised mHABP mixtures can be designed for developing vaccines against diseases scourging humankind, malaria being one of them. © 2014 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2014.02.003
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23461
dc.language.isoengspa
dc.publisherElsevier BVspa
dc.relation.citationEndPage2126
dc.relation.citationIssueNo. 18
dc.relation.citationStartPage2117
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 32
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.32, No.18 (2014); pp. 2117-2126spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896548606&doi=10.1016%2fj.vaccine.2014.02.003&partnerID=40&md5=c760298d7f029fff1752b8dc316cca14spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordprotozoaneng
dc.subject.keywordPeptide vaccinespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordVery high long lasting antibody inducing modified high activity binding peptidespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAotusspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug mixturespa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordGauche side chain orientationspa
dc.subject.keywordGenotypespa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunofluorescencespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtectionspa
dc.subject.keywordProtein structurespa
dc.subject.keywordProton nuclear magnetic resonancespa
dc.subject.keywordSporozoitespa
dc.subject.keywordVaccinationspa
dc.subject.keywordWestern blottingspa
dc.subject.keywordAntimalarial vaccinespa
dc.subject.keywordGauche(+)spa
dc.subject.keywordPeptide mixturesspa
dc.subject.keywordProtective immunityspa
dc.subject.keyword?(1) anglespa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntibody formationspa
dc.subject.keywordAotus trivirgatusspa
dc.subject.keywordBinding sitesspa
dc.subject.keywordHla-dr beta-chainsspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordOligopeptidesspa
dc.subject.keywordProtein conformationspa
dc.subject.keywordAntimalarial vaccinespa
dc.subject.keywordPeptide mixturesspa
dc.subject.keywordProtective immunityspa
dc.titleGauche+ side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccinespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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