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The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia

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dc.creatorKerr, Jonathan R.spa
dc.creatorMattey, Derek L.spa
dc.date.accessioned2020-05-25T23:58:55Z
dc.date.available2020-05-25T23:58:55Z
dc.date.created2015spa
dc.description.abstractIn this article, we review the evidence suggesting a possible role for B19 virus in the pathogenesis of a subset of cases of acute leukemia. Human parvovirus B19 infection may complicate the clinical course of patients with acute leukemia and may also precede the development of acute leukemia by up to 180days. Parvovirus B19 targets erythroblasts in the bone marrow and may cause aplastic crisis in patients with shortened-red cell survival. Aplastic crisis represents a prodrome of acute lymphoblastic leukemia in 2% patients. There is a significant overlap between those HLA classes I and II alleles that are associated with a vigorous immune response and development of symptoms during B19 infection and those HLA alleles that predispose to development of acute leukemia. Acute symptomatic B19 infection is associated with low circulating IL-10 consistent with a vigorous immune response; deficient IL-10 production at birth was recently found to be associated with subsequent development of acute leukemia. Anti-B19 IgG has been associated with a particular profile of methylation of human cancer genes in patients with acute leukemia, suggesting an additional hit and run mechanism. The proposed role for parvovirus B19 in the pathogenesis of acute leukemia fits well with the delayed infection hypothesis and with the two-step mutation model, which describes carriage of the first mutation prior to birth, followed by suppression of hematopoiesis, which allows rapid proliferation of cells harboring the first mutation, acquisition of a second activating mutation, and expansion of cells carrying both mutations, resulting in acute leukemia. © 2015 John Wiley and Sons, Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/rmv.1830
dc.identifier.issn10529276
dc.identifier.issn10991654
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22951
dc.language.isoengspa
dc.publisherJohn Wiley and Sons Ltdspa
dc.relation.citationEndPage155
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage133
dc.relation.citationTitleReviews in Medical Virology
dc.relation.citationVolumeVol. 25
dc.relation.ispartofReviews in Medical Virology, ISSN:10529276, 10991654, Vol.25, No.3 (2015); pp. 133-155spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928770767&doi=10.1002%2frmv.1830&partnerID=40&md5=4fe47e952cc53105e4d4dd6d0773bf0aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntineoplastic agentspa
dc.subject.keywordviraleng
dc.subject.keywordHla antigen class 2spa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordInterleukin 10spa
dc.subject.keywordAntineoplastic agentspa
dc.subject.keywordAcute leukemiaspa
dc.subject.keywordAcute lymphoblastic leukemiaspa
dc.subject.keywordAllelespa
dc.subject.keywordAplastic crisisspa
dc.subject.keywordCancer chemotherapyspa
dc.subject.keywordCancer diagnosisspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease coursespa
dc.subject.keywordErythroblastspa
dc.subject.keywordErythrocyte lifespanspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman parvovirus b19 infectionspa
dc.subject.keywordImmune responsespa
dc.subject.keywordMethylationspa
dc.subject.keywordMutationspa
dc.subject.keywordParvovirus infectionspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordReviewspa
dc.subject.keywordTumor genespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordCase reportspa
dc.subject.keywordChildspa
dc.subject.keywordComplicationspa
dc.subject.keywordFemalespa
dc.subject.keywordHuman parvovirus b19spa
dc.subject.keywordImmunologyspa
dc.subject.keywordInfantspa
dc.subject.keywordLeukemiaspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordParvovirus infectionspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPreschool childspa
dc.subject.keywordTime factorspa
dc.subject.keywordVirologyspa
dc.subject.keywordVirus cell transformationspa
dc.subject.keywordVirus infectionspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAntineoplastic combined chemotherapy protocolsspa
dc.subject.keywordCell transformationeng
dc.subject.keywordChildspa
dc.subject.keywordChildeng
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInfantspa
dc.subject.keywordLeukemiaspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordParvoviridae infectionsspa
dc.subject.keywordParvovirus b19eng
dc.subject.keywordTime factorsspa
dc.subject.keywordVirus diseasesspa
dc.subject.keywordYoung adultspa
dc.titleThe role of parvovirus B19 and the immune response in the pathogenesis of acute leukemiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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