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Genetic basis of Sjögren's syndrome. How strong is the evidence?

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dc.audienceComunidad Rosaristaspa
dc.creatorAnaya, Juan-Manuel
dc.creatorDelgado Vega, Angélica María
dc.creatorCastiblanco, John
dc.creator.googleAnaya, Juan-Manuel
dc.creator.googleDelgado Vega, Angélica María
dc.creator.googleCastiblanco, John
dc.date.accessioned2014-08-13T18:54:08Z
dc.date.available2014-08-13T18:54:08Z
dc.date.created2006
dc.date.issued2006
dc.description.abstractSjögren's syndrome (SS) is a late-onset chronic autoimmune disease (AID) affecting the exocrine glands, mainly the salivary and lachrymal. Genetic studies on twins with primary SS have not been performed, and only a few case reports describing twins have been published. The prevalence of primary SS in siblings has been estimated to be 0.09% while the reported general prevalence of the disease is approximately 0.1%. The observed aggregation of AIDs in families of patients with primary SS is nevertheless supportive for a genetic component in its etiology. In the absence of chromosomal regions identified by linkage studies, research has focused on candidate gene approaches (by biological plausibility) rather than on positional approaches. Ancestral haplotype 8.1 as well as TNF, IL10 and SSA1 loci have been consistently associated with the disease although they are not specific for SS. In this review, the genetic component of SS is discussed on the basis of three known observations: (a) age at onset and sex-dependent presentation, (b) familial clustering of the disease, and (c) dissection of the genetic component. Since there is no strong evidence for a specific genetic component in SS, a large international and collaborative study would be suitable to assess the genetics of this disorder.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1080/17402520600876911
dc.identifier.issnISSN:1740-2522
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8836
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 2
dc.relation.citationTitleClinical & Developmental Immunology
dc.relation.citationVolumeVol. 13
dc.relation.ispartofClinical & Developmental Immunology ISSN 1740-2522 V. 13 N. 2-4 Jun, 2006spa
dc.relation.urihttp://web.a.ebscohost.com.ez.urosario.edu.co/ehost/pdfviewer/pdfviewer?sid=12158b70-776b-43d0-8069-ce5f294e3918%40sessionmgr4003&vid=2&hid=4101
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcIncidencia & prevención de la enfermedad
dc.subject.decsSíndrome de Sjögrenspa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.decsInmunologíaspa
dc.subject.keywordCHRM3eng
dc.subject.keywordIL10eng
dc.subject.keywordSjögren's syndromeeng
dc.subject.keywordSSA1eng
dc.titleGenetic basis of Sjögren's syndrome. How strong is the evidence?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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