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HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies

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dc.creatorCruz-Tapias, Paolaspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorMaier-Moore, Shannonspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:00:04Z
dc.date.available2020-05-26T00:00:04Z
dc.date.created2012spa
dc.description.abstractThe aim of this work was to identify common HLA Class II alleles contributing to primary Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological implications through a binding prediction approach of peptides from major pSS auto-antigens. Case-control studies on HLA-DQ and HLA-DR in pSS were searched in various literature databases through April 2011 by a systematic review. The effect summary odds ratios and 95% confidence intervals were obtained by means of the random effect model. A total of 1166 cases and 6470 controls from 23 studies were analyzed. At the allelic level, DQA1 *05:01, DQB1 *02:01, and DRB1 *03:01 alleles were found to be risk factors for disease. Conversely, the DQA1 *02:01, DQA1 *03:01 and DQB1 *05:01 alleles were protective factors. The current study stresses the significant size effect HLA exhibits in the development of pSS. Analysis of susceptibility and protective alleles revealed physicochemical differences in critical amino acids located within the antigen-binding groove of DR?, DQ? and DQ? chains, allowing us to infer a mechanistic approach to understand the role of HLA in pSS and other autoimmune diseases. © 2011 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2011.10.002
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23155
dc.language.isoengspa
dc.relation.citationEndPage287
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage281
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 11
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.11, No.4 (2012); pp. 281-287spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84857061990&doi=10.1016%2fj.autrev.2011.10.002&partnerID=40&md5=f0342bd467aa16178e07179e059f7105spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordgeneticeng
dc.subject.keywordPeptidespa
dc.subject.keywordAllelespa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordCase control studyspa
dc.subject.keywordData basespa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordHla systemspa
dc.subject.keywordHla typingspa
dc.subject.keywordHumanspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordAmino acid motifsspa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordComputational biologyspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHistocompatibility antigens class iispa
dc.subject.keywordHumansspa
dc.subject.keywordPeptide fragmentsspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtein bindingspa
dc.subject.keywordRibonucleoproteinsspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordHla antigensspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordPrimary sjögren's syndromespa
dc.titleHLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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