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GC3 of genes can be used as a proxy for isochore base composition: A reply to Elhaik et al.

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dc.creatorClay O.K.spa
dc.creatorBernardi G.spa
dc.date.accessioned2020-05-25T23:57:06Z
dc.date.available2020-05-25T23:57:06Z
dc.date.created2011spa
dc.description.abstractIn an article published in these pages, Elhaik et al. (Elhaik E, Landan G, Graur D. 2009. Can GC content at third-codon positions be used as a proxy for isochore composition? Mol Biol Evol. 26:1829-1833) asked if GC3, the GC level of the third-codon positions in protein-coding genes, can be used as a 'proxy' to estimate the GC level of the surrounding isochore. We use available data to directly answer this simple question in the affirmative and show how the use of indirect methods can lead to apparently conflicting conclusions. The answer reasserts that in human and other vertebrates, genes have a strong tendency to reside in compositionally corresponding isochores, which has far-reaching implications for genome structure and evolution. © 2010 The Author.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/molbev/msq222
dc.identifier.issn15371719
dc.identifier.issn07374038
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22606
dc.language.isoengspa
dc.relation.citationEndPage23
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage21
dc.relation.citationTitleMolecular Biology and Evolution
dc.relation.citationVolumeVol. 28
dc.relation.ispartofMolecular Biology and Evolution, ISSN:15371719, 07374038, Vol.28, No.1 (2011); pp. 21-23spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78650460796&doi=10.1093%2fmolbev%2fmsq222&partnerID=40&md5=a8c061287e62ce3c2feeeeaf1fd2d28dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDnaspa
dc.subject.keywordCodonspa
dc.subject.keywordDna base compositionspa
dc.subject.keywordDna flanking regionspa
dc.subject.keywordGc rich sequencespa
dc.subject.keywordIsochorespa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordReviewspa
dc.subject.keywordAnimalsspa
dc.subject.keywordBase compositionspa
dc.subject.keywordCodonspa
dc.subject.keywordEvolutioneng
dc.subject.keywordGenomespa
dc.subject.keywordHumansspa
dc.subject.keywordIsochoresspa
dc.subject.keywordVertebrataspa
dc.subject.keywordChromatinspa
dc.subject.keywordGc levelspa
dc.subject.keywordGc3spa
dc.subject.keywordGenome compositionspa
dc.subject.keywordIsochoresspa
dc.subject.keywordLong-range correlationsspa
dc.titleGC3 of genes can be used as a proxy for isochore base composition: A reply to Elhaik et al.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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