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Infections and vaccines in the etiology of antiphospholipid syndrome

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dc.creatorCruz-Tapias, Paolaspa
dc.creatorBlank, Mirispa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-26T00:05:45Z
dc.date.available2020-05-26T00:05:45Z
dc.date.created2012spa
dc.description.abstractPurpose of review: To present scientific evidence supporting the infectious origin for the antiphospholipid syndrome (APS) by molecular mimicry between pathogens, infection and vaccination with ?2-glycoprotein I (?2-GPI) molecule. Recent findings: APS is characterized by the presence of pathogenic autoantibodies against ?2-GPI. The infection etiology of APS was well established. Likewise, a link between vaccination such as tetanus toxoid may trigger antibodies targeting tetanus toxoid and ?2-GPI, due to molecular mimicry between the two molecules. During the years, the pathogenic potential of anti-tetanus toxoid antibodies cross reactive with ?2-GPI were found to be pathogenic in animal models, inducing experimental APS. Summary: Accumulated evidence supports that the presence of anti-?2-GPI antibodies is associated with a history of infections and the main mechanism to explain this correlation is molecular mimicry. The relationship between tetanus toxoid vaccination and APS reveals a novel view on the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). © 2012 Wolters Kluwer Healtheng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/BOR.0b013e32835448b8
dc.identifier.issn15316963
dc.identifier.issn10408711
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23823
dc.language.isoengspa
dc.relation.citationEndPage393
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage389
dc.relation.citationTitleCurrent Opinion in Rheumatology
dc.relation.citationVolumeVol. 24
dc.relation.ispartofCurrent Opinion in Rheumatology, ISSN:15316963, 10408711, Vol.24, No.4 (2012); pp. 389-393spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84862149521&doi=10.1097%2fBOR.0b013e32835448b8&partnerID=40&md5=283b8aa73cebb6a83a3f0832195b9b68spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword4 aminobutyric acidspa
dc.subject.keywordimmunologiceng
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordBeta2 glycoprotein 1spa
dc.subject.keywordBeta2 glycoprotein 1 antibodyspa
dc.subject.keywordCardiolipin antibodyspa
dc.subject.keywordDiphtheria antibodyspa
dc.subject.keywordGanglioside antibodyspa
dc.subject.keywordGlycerolspa
dc.subject.keywordImmunoglobulin a antibodyspa
dc.subject.keywordImmunoglobulin g antibodyspa
dc.subject.keywordImmunoglobulin m antibodyspa
dc.subject.keywordInterleukin 1 receptorspa
dc.subject.keywordLamininspa
dc.subject.keywordMyeloid differentiation factor 88spa
dc.subject.keywordTetanus toxoidspa
dc.subject.keywordToll like receptorspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoinflammatory diseasespa
dc.subject.keywordBlood clotting timespa
dc.subject.keywordClostridium tetanispa
dc.subject.keywordCross reactionspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFetus wastagespa
dc.subject.keywordHumanspa
dc.subject.keywordInfectionspa
dc.subject.keywordMedical historyspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPartial thromboplastin timespa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordTetanus prophylaxisspa
dc.subject.keywordThrombocytopeniaspa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordBeta 2-glycoprotein ispa
dc.subject.keywordCross reactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordInfectionspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordTetanus toxoidspa
dc.subject.keyword?2-glycoprotein ispa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordTetanus toxoidspa
dc.titleInfections and vaccines in the etiology of antiphospholipid syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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