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Transcriptomic changes across the life cycle of Trypanosoma cruzi II

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dc.creatorCruz-Saavedra, Lissaspa
dc.creatorVallejo, Gustavo A.spa
dc.creatorGuhl, Felipespa
dc.creatorRamírez González, Juan Davidspa
dc.date.accessioned2020-06-11T13:22:12Z
dc.date.available2020-06-11T13:22:12Z
dc.date.created2020spa
dc.description.abstractTrypanosoma cruzi is a flagellated protozoan that causes Chagas disease; it presents a complex life cycle comprising four morphological stages: epimastigote (EP), metacyclic trypomastigote (MT), cell-derived trypomastigote (CDT) and amastigote (AM). Previous transcriptomic studies on three stages (EPs, CDTs and AMs) have demonstrated differences in gene expressions among them; however, to the best of our knowledge, no studies have reported on gene expressions in MTs. Therefore, the present study compared differentially expressed genes (DEGs), and signaling pathway reconstruction in EPs, MTs, AMs and CDTs. The results revealed differences in gene expressions in the stages evaluated; these differences were greater between MTs and AMs-PTs. The signaling pathway that presented the highest number of DEGs in all the stages was associated with ribosomes protein profiles, whereas the other related pathways activated were processes related to energy metabolism from glucose, amino acid metabolism, or RNA regulation. However, the role of autophagy in the entire life cycle of T. cruzi and the presence of processes such as meiosis and homologous recombination in MTs (where the expressions of SPO11 and Rad51 plays a role) are crucial. These findings represent an important step towards the full understanding of the molecular basis during the life cycle of T. cruzi.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.7717/peerj.8947
dc.identifier.issn2167-8359
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25053
dc.language.isoeng
dc.publisherPeerJspa
dc.relation.citationEndPage
dc.relation.citationStartPagee8947
dc.relation.citationTitlePEERJ
dc.relation.citationVolumeVol. 8
dc.relation.ispartofPEERJ, ISSN:2167-8359, Vol.8, (2020); pp. e8947-spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectTrypanosoma cruzispa
dc.subjectTripomastigotes metacíclicosspa
dc.subjectEpimastigotesspa
dc.subjectTripomastigotesspa
dc.subjectTranscriptómicaspa
dc.subjectCaminosspa
dc.subjectIntercambio genéticospa
dc.subjectEl perfil revelaspa
dc.subjectExpresiónspa
dc.subjectMitosisspa
dc.subjectEupathdbspa
dc.subjectSombrero de copaspa
dc.subjectAgentespa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordMetacyclic trypomastigotesspa
dc.subject.keywordEpimastigotesspa
dc.subject.keywordTrypomastigotesspa
dc.subject.keywordTranscriptomicspa
dc.subject.keywordPathwaysspa
dc.subject.keywordGenetic exchangespa
dc.subject.keywordProfiling revealsspa
dc.subject.keywordExpressionspa
dc.subject.keywordMeiosisspa
dc.subject.keywordEupathdbspa
dc.subject.keywordTophatspa
dc.subject.keywordAgentspa
dc.titleTranscriptomic changes across the life cycle of Trypanosoma cruzi IIspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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