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Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos

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dc.creatorOspina, Dianaspa
dc.creatorVillegas Gálvez, Victoria Eugenia
dc.creatorRodriguez-Leguizamon, Giovanni
dc.creatorRondón-Lagos, Milenaspa
dc.date.accessioned2020-05-26T00:03:52Z
dc.date.available2020-05-26T00:03:52Z
dc.date.created2019spa
dc.description.abstractAsbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure. © 2019 Zhang et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2147/CMAR.S205723
dc.identifier.issn11791322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23635
dc.language.isoengspa
dc.publisherDove Medical Press Ltdspa
dc.relation.citationEndPage5012
dc.relation.citationStartPage4997
dc.relation.citationTitleCancer Management and Research
dc.relation.citationVolumeVol. 11
dc.relation.ispartofCancer Management and Research, ISSN:11791322, Vol.11,(2019); pp. 4997-5012spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85067957322&doi=10.2147%2fCMAR.S205723&partnerID=40&md5=5c3b9a2aacab95249a189cb48666cb03spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnaplastic lymphoma kinasespa
dc.subject.keywordAquaporin 1spa
dc.subject.keywordAsbestosspa
dc.subject.keywordCyclin dependent kinase inhibitor 2aspa
dc.subject.keywordCyclin dependent kinase inhibitor 2bspa
dc.subject.keywordEpidermal growth factor receptorspa
dc.subject.keywordFibronectinspa
dc.subject.keywordFibulinspa
dc.subject.keywordFibulin 3spa
dc.subject.keywordFragile histidine triad proteinspa
dc.subject.keywordHigh mobility group b1 proteinspa
dc.subject.keywordImmunoglobulin enhancer binding proteinspa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordInterleukin 8spa
dc.subject.keywordMesothelinspa
dc.subject.keywordMessenger rnaspa
dc.subject.keywordMitogen activated protein kinasespa
dc.subject.keywordMitogen activated protein kinase 1spa
dc.subject.keywordMitogen activated protein kinase 3spa
dc.subject.keywordOsteopontinspa
dc.subject.keywordReactive nitrogen speciesspa
dc.subject.keywordReactive oxygen metabolitespa
dc.subject.keywordSoluble mesothelin related proteinspa
dc.subject.keywordTranscription factor ap 1spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAlk genespa
dc.subject.keywordAngiogenesisspa
dc.subject.keywordAsbestosisspa
dc.subject.keywordBap1 genespa
dc.subject.keywordCancer riskspa
dc.subject.keywordCause of deathspa
dc.subject.keywordCdkn2a genespa
dc.subject.keywordCdkn2b genespa
dc.subject.keywordChromosome damagespa
dc.subject.keywordCul1 genespa
dc.subject.keywordDna damagespa
dc.subject.keywordFhit genespa
dc.subject.keywordFibrogenesisspa
dc.subject.keywordGenespa
dc.subject.keywordGene mutationspa
dc.subject.keywordGene rearrangementspa
dc.subject.keywordGenetic damagespa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordHumanspa
dc.subject.keywordLung alveolus cell type 2spa
dc.subject.keywordLung alveolus macrophagespa
dc.subject.keywordLung cancerspa
dc.subject.keywordMapk signalingspa
dc.subject.keywordMesotheliomaspa
dc.subject.keywordMet genespa
dc.subject.keywordNf2 genespa
dc.subject.keywordNonhumanspa
dc.subject.keywordOccupational exposurespa
dc.subject.keywordOxidative stressspa
dc.subject.keywordPathogenicityspa
dc.subject.keywordProtein phosphorylationspa
dc.subject.keywordReviewspa
dc.subject.keywordSmokingspa
dc.subject.keywordWorkplacespa
dc.subject.keywordCancerspa
dc.subject.keywordCellular damagespa
dc.subject.keywordGenomic damagespa
dc.subject.keywordOccupational exposurespa
dc.titleAnalyzing biological and molecular characteristics and genomic damage induced by exposure to asbestosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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