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Persistence of clonal azole-resistant isolates of Candida albicans from a patient with chronic mucocutaneous candidiasis in Colombia

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dc.creatorCeballos-Garzon, Andrésspa
dc.creatorWintaco-Martínez, Luz Mspa
dc.creatorVelez, Noridaspa
dc.creatorHernandez-Padilla, Catalinaspa
dc.creatorDe la Hoz, Alejandrospa
dc.creatorValderrama-Beltrán, Sandra Lilianaspa
dc.creatorAlvarez-Moreno, Carlos Aspa
dc.creatorPape, Patrice Lespa
dc.creatorRamírez, Juan Davidspa
dc.creatorParra-Giraldo, Claudia Mspa
dc.date.accessioned2020-05-25T23:56:12Z
dc.date.available2020-05-25T23:56:12Z
dc.date.created2020spa
dc.description.abstractPurpose: The present article describes retrospectively a case of a patient with chronic mucocutaneous candidiasis (CMC) who presented recurrent Candida albicans infection since he was 6 months old. We obtained 16 isolates recovered during a 4-year period. Our purpose was to determinate the susceptibility, genotyping, and the pathogenicity profile in all the isolates. Methods: Sixteen C. albicans were isolated from a 25-year-old male with several recurrent fungal infections admitted to Hospital. The isolates were recovered during 4 years from a different anatomical origin. We typified them by multilocus sequence typing, also we evaluated susceptibility to fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, caspofungin, and amphotericin B by microdilution method and we also test the pathogenic capacity in the Galleria mellonella model. Results: Genotyping of all clinical isolates showed the persistence of the same diploid sequence type (DST). Isolates changed their susceptibility profile over time, but there were no significant statistical differences in pathogenicity. Conclusion: Herein, a persistent clonal isolates of C. albicans (DST 918) in a patient with CMC, showed changes in its susceptibility profile after several antifungal treatments acquiring gradual resistance to the azole drugs, which did not affect their pathogenicity. © 2020 Journal of Global Infectious Diseaseseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4103/jgid.jgid_74_19
dc.identifier.issn0974777X
dc.identifier.issn09748245
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22358
dc.language.isoengspa
dc.publisherWolters Kluwer Medknow Publicationsspa
dc.relation.citationEndPage20
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage16
dc.relation.citationTitleJournal of Global Infectious Diseases
dc.relation.citationVolumeVol. 12
dc.relation.ispartofJournal of Global Infectious Diseases, ISSN:0974777X, 09748245, Vol.12, No.1 (2020); pp. 16-20spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081575362&doi=10.4103%2fjgid.jgid_74_19&partnerID=40&md5=9000ccdf18d1850d77e0ac24f96cdb1aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmphotericin Bspa
dc.subject.keywordCaspofunginspa
dc.subject.keywordFluconazolespa
dc.subject.keywordIsavuconazolespa
dc.subject.keywordItraconazolespa
dc.subject.keywordPosaconazolespa
dc.subject.keywordPyrrolespa
dc.subject.keywordVoriconazolespa
dc.subject.keywordAdultspa
dc.subject.keywordAntifungal resistancespa
dc.subject.keywordAntifungal therapyspa
dc.subject.keywordArticlespa
dc.subject.keywordBroth dilutionspa
dc.subject.keywordCandida albicansspa
dc.subject.keywordCase reportspa
dc.subject.keywordClinical articlespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordFungus culturespa
dc.subject.keywordFungus isolationspa
dc.subject.keywordGalleria mellonellaspa
dc.subject.keywordHospital admissionspa
dc.subject.keywordHumanspa
dc.subject.keywordMalespa
dc.subject.keywordMatrix assisted laser desorption ionization time of flight mass spectrometryspa
dc.subject.keywordMedical historyspa
dc.subject.keywordMucocutaneous candidiasisspa
dc.subject.keywordMultilocus sequence typingspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenicityspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordCandida albicansspa
dc.subject.keywordChronic mucocutaneous candidiasisspa
dc.subject.keywordDrug susceptibilityspa
dc.subject.keywordGalleria mellonellaspa
dc.subject.keywordMultilocus sequence typingspa
dc.titlePersistence of clonal azole-resistant isolates of Candida albicans from a patient with chronic mucocutaneous candidiasis in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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