Immunosenescence, Aging, and Systemic Lupus Erythematous

Montoya-Ortiz, Gladis

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Immunosenescence, Aging, and Systemic Lupus Erythematous

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dc.audience	Comunidad Rosarista	spa
dc.creator	Montoya-Ortiz, Gladis
dc.creator.google	Montoya-Ortiz, Gladis
dc.date.accessioned	2014-08-11T18:23:07Z
dc.date.available	2014-08-11T18:23:07Z
dc.date.created	2013
dc.date.issued	2013
dc.description.abstract	Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.). These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity. This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients	eng
dc.format.medium	Recurso electrónico	spa
dc.format.mimetype	application/pdf
dc.format.tipo	Documento	spa
dc.identifier.issn	ISSN:2090-0430
dc.identifier.uri	http://repository.urosario.edu.co/handle/10336/8772
dc.language.iso	eng
dc.publisher	Universidad del Rosario	spa
dc.relation.citationTitle	Autoimmune Diseases
dc.relation.ispartof	Autoimmune Diseases, ISSN 2090-04-30, 2013	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto completo)	spa
dc.rights.licencia	EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.	spa
dc.source.instname	instname:Universidad del Rosario	spa
dc.source.reponame	reponame:Repositorio Institucional EdocUR	spa
dc.subject.ddc	Biología
dc.subject.decs	Lupus Eritematoso Sistémico	spa
dc.subject.decs	Enfermedades autoinmunes	spa
dc.subject.decs	Inmunología	spa
dc.title	Immunosenescence, Aging, and Systemic Lupus Erythematous	spa
dc.type	article	eng
dc.type.hasVersion	info:eu-repo/semantics/acceptedVersion
dc.type.spa	Artículo	spa