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Comparison of Bi 2 S 3 and Ta 2 O 5 as alternative materials to gold in nanoparticles used as agents to increase the dose in radiotherapy

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dc.creatorAlejo-Martinez, Harleyspa
dc.creatorSevilla-Moreno, Andrés C.spa
dc.creatorOndo Méndez, Alejandro Oyono
dc.creatorQuintero, Jorge H.spa
dc.creatorPáez, Carlos J.spa
dc.date.accessioned2020-05-25T23:56:28Z
dc.date.available2020-05-25T23:56:28Z
dc.date.created2019spa
dc.description.abstractRadiotherapy is an essential component in the treatment of all types of cancer. Radiotherapy uses ionizing radiation to destroy tumor tissue while reducing the damage to normal tissue as much as possible. In this work we study the effects of the spherical Bi 2 S 3 and Ta 2 O 5 nanoparticles (NPs) used as a radio-sensitization agent to increase local doses around the nanoparticle in a water medium. For low energy X-rays the dominant interaction is the photoelectric effect, which involves the absorption of a photon and the subsequent production of photoelectrons, characteristic X-rays and Auger electrons. Using a GEANT4 based simulation was determined the kinetic energy spectra of secondary electrons produced by the interaction of X-ray beam and Au, Bi 2 S 3 and Ta 2 O 5 NPs, after that was calculated the interaction processes, energy deposited, absorbed dose and the effective range distributions for the secondary electrons generated by the interaction of 100 million incident photons in the nanoparticles. The size of the nanoparticles was 20 nm and the energy distribution of the photons corresponds to the spectrum of a tube of x-rays with Tungsten anode and a peak voltage applied of 40 kV. This study demonstrates that Bi 2 S 3 and Ta 2 O 5 NPs are a viable alternative to Au NPs as a dose enhancing agent in radiotherapy. © Published under licence by IOP Publishing Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1088/1742-6596/1247/1/012050
dc.identifier.issn17426588
dc.identifier.issn17426596
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22434
dc.language.isoengspa
dc.publisherInstitute of Physics Publishingspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleJournal of Physics: Conference Series
dc.relation.citationVolumeVol. 1247
dc.relation.ispartofJournal of Physics: Conference Series, ISSN:17426588, 17426596, Vol.1247, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073886352&doi=10.1088%2f1742-6596%2f1247%2f1%2f012050&partnerID=40&md5=c544bd2b3c939dfd139132318a21761cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEngineering researchspa
dc.subject.keywordGold depositsspa
dc.subject.keywordGold nanoparticlesspa
dc.subject.keywordKinetic energyspa
dc.subject.keywordKineticsspa
dc.subject.keywordNanoparticlesspa
dc.subject.keywordPhotoelectricityspa
dc.subject.keywordPhotonsspa
dc.subject.keywordRadiotherapyspa
dc.subject.keywordSecondary emissionspa
dc.subject.keywordTissuespa
dc.subject.keywordAlternative materialsspa
dc.subject.keywordCharacteristic x raysspa
dc.subject.keywordEnergy distributionsspa
dc.subject.keywordInteraction processspa
dc.subject.keywordKinetic energy spectraspa
dc.subject.keywordNanoparticle (nps)spa
dc.subject.keywordRadio-sensitizationspa
dc.subject.keywordSecondary electronsspa
dc.subject.keywordX raysspa
dc.titleComparison of Bi 2 S 3 and Ta 2 O 5 as alternative materials to gold in nanoparticles used as agents to increase the dose in radiotherapyspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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