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HIV-1 transmitted drug resistance in latin America and the Caribbean: What do we know?

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dc.creatorPineda-Peña A.-C.spa
dc.creatorBello D.-C.spa
dc.creatorSussmann O.spa
dc.creatorVandamme A.-M.spa
dc.creatorVercauteren J.spa
dc.creatorVan Laethem K.spa
dc.creatorGómez-López A.spa
dc.date.accessioned2020-05-26T00:07:00Z
dc.date.available2020-05-26T00:07:00Z
dc.date.created2012spa
dc.description.abstractLatin America and the Caribbean countries have increased the scaling-up of antiretroviral treatment in the last years. The increase of transmitted drug resistance has been feared due to the worrisome indicators associated with the emergence of drug resistance and monitored by the World Health Organization (WHO). Consequently, our aim was to review all relevant studies on transmitted drug resistance in Latin America and the Caribbean countries, to analyze its levels, to identify the frequency of transmitted drug resistance mutations, and to put these results in the context of the local Latin American and Caribbean countries settings. A systematic search of Spanish, Portuguese, and English literature was performed in databases and international conferences for the period June 1999 to May 2011. In addition, sequences were downloaded from the Los Alamos and Stanford databases and the transmitted drug resistance was reanalyzed according to the WHO Surveillance Drug Resistance Mutation list 2009. In total, 50 articles, 27 abstracts, and 1,922 patients were included. The resistance varied geographically, but most of the countries have reached the WHO threshold of 5% of resistance. According to the sequences available in public databases, the overall prevalence in Latin America and the Caribbean countries for the period 1996-2009 was 7.7% and by region it was 4.3% for the Caribbean, 3.9% for Mexico, 9.4% for Brazil, 10.5% for the Andean region and 4.9% for the Southern Cone. For the last four investigated years (2006-2009), the information was restricted to Brazilian and Venezuelan studies and revealed an overall transmitted drug resistance of 10%. Throughout the study period, limited information was available for the Caribbean and Central American countries. These findings support the need for developing comprehensive surveys of transmitted drug resistance in these regions.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn11396121
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23952
dc.language.isoengspa
dc.relation.citationEndPage267
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage256
dc.relation.citationTitleAIDS Reviews
dc.relation.citationVolumeVol. 14
dc.relation.ispartofAIDS Reviews, ISSN:11396121, Vol.14, No.4 (2012); pp. 256-267spa
dc.relation.urihttps://app.dimensions.ai/details/publication/pub.1078664397spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordNevirapinespa
dc.subject.keywordviraleng
dc.subject.keywordZidovudinespa
dc.subject.keywordBlood toxicityspa
dc.subject.keywordBrazilspa
dc.subject.keywordCd4 lymphocyte countspa
dc.subject.keywordCentral americaspa
dc.subject.keywordFollow upspa
dc.subject.keywordGene mutationspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHeterosexual malespa
dc.subject.keywordHighly active antiretroviral therapyspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1 infectionspa
dc.subject.keywordMexicospa
dc.subject.keywordPrevalencespa
dc.subject.keywordRashspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSocioeconomicsspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordVenezuelaspa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordWorld health organizationspa
dc.subject.keywordCaribbean regionspa
dc.subject.keywordDrug resistanceeng
dc.subject.keywordFemalespa
dc.subject.keywordGuidelines as topicspa
dc.subject.keywordHiv infectionsspa
dc.subject.keywordHiv-1spa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMalespa
dc.subject.keywordMutationeng
dc.subject.keywordPrevalencespa
dc.subject.keywordCaribbeanspa
dc.subject.keywordDrug resistancespa
dc.subject.keywordGenotypespa
dc.subject.keywordHiv-1spa
dc.subject.keywordLatin americaspa
dc.subject.keywordNaivespa
dc.titleHIV-1 transmitted drug resistance in latin America and the Caribbean: What do we know?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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