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Eficacia de los inhibidores selectivos de recaptación de serotonina en síntomas no cognitivos del alzhéimer: revisión sistemática

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dc.contributor.advisorVallejo Silva, Alexie
dc.contributor.advisorMorón Duarte, Lina Sofía
dc.creatorTapasco Alzate, Wolmar Olmedo
dc.creator.degreeEspecialista en Psiquiatría
dc.date.accessioned2013-01-30T19:44:48Z
dc.date.available2013-01-30T19:44:48Z
dc.date.created2013-01-21
dc.date.issued2013
dc.descriptionIntroducción: El Alzhéimer tiene una prevalencia de 1,6% en las personas mayores de 65 años. Se caracteriza por la pérdida de memoria y otras funciones cognoscitivas, pero más del 70% de los afectados presentan síntomas no cognitivos entre los que se encuentran alteraciones del afecto, comportamiento y psicosis. Estos síntomas están asociados a mayores tasas de institucionalización, morbilidad y mortalidad. Métodos: Revisión sistemática de la literatura de artículos que proporcionaron información sobre la eficacia de los inhibidores selectivos de recaptación de serotonina en síntomas no cognitivos del Alzhéimer. Resultados: La búsqueda inicial arrojó un total de 495 resultados, 64 artículos fueron preseleccionados y 7 se incluyeron en la revisión; éstos se clasificaron como nivel de evidencia Ib; citalopram mostró ser más eficaz que el placebo y similar a antipsicóticos para síntomas comportamentales y psicóticos asociados al Alzhéimer con un perfil de efectos adversos más tolerable; sertralina no mostró eficacia en depresión y sí una mayor incidencia de efectos adversos con respecto al placebo. Discusión: Se obtuvieron resultados favorables en síntomas comportamentales y psicóticos pero no en afectivos. Las diferencias metodológicas de los estudios le dan complejidad a la interpretación de los resultados. Conclusión: La evidencia sugiere que el tratamiento con citalopram es eficaz en síntomas comportamentales y psicóticos asociados al Alzhéimer; para el tratamiento de la depresión asociado a esta demencia aún no existe un antidepresivo que pueda considerarse de elección.spa
dc.description.abstractIntroduction: Alzheimer’s disease has a 1. 6% of prevalence in people over 65 years of age. It is characterized by loss of memory and other cognitive functions, but more of the 70% of affected have non-cognitive symptoms as alterations of mood, behavior and psychosis. These symptoms are associated to increased rates of institutionalization, morbidity and mortality. Methods: Systematic review of literature from papers that provided information about efficacy of selective serotonin reuptake inhibitors in Alzheimer’s non-cognitive symptoms. Results: Initial search resulted in 495 papers, 64 articles were pre-selected and 7 were included in review, these were classified as level of evidence Ib, Citalopram showed to be more effective than placebo and similar to antipsychotics for behavioral and psychotic symptoms of Alzheimer’s disease with more tolerable profile of adverse effects; Sertraline didn’t show efficacy in depression but an increased incidence of adverse effects compared against placebo. Discussion: Favorable results were achieved in behavioral and psychotic symptoms but not in emotional symptoms. Methodological differences among the studies give complexity to interpretation of results. Conclusions: Evidence suggests that Citalopram’s treatment is effective in behavioral and psychotic symptoms associated to Alzheimer’s disease; for treatment of depression associated to this dementia does not yet exist an antidepressant that can consider treatment of choice. eng
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dc.identifier.doihttps://doi.org/10.48713/10336_4152
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/4152
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Psiquiatríaspa
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dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectInhibidores selectivos de recaptación de serotoninaspa
dc.subjectenfermedad de Alzheimerspa
dc.subjectsíntomas comportamentales y psicológicos de la demenciaspa
dc.subject.keywordSelective serotonin reuptake inhibitorseng
dc.subject.keywordAlzheimer’s diseaseeng
dc.subject.keywordbehavioral and psychological symptoms of dementiaeng
dc.subject.lembEnfermedad de alzhéimer::Investigacionesspa
dc.subject.lembCitalopram::Administración & Dosificaciónspa
dc.subject.lembInhibidores de captación de serotonina::Administración & Dosificaciónspa
dc.subject.lembPsiquiatría::Investigacionesspa
dc.titleEficacia de los inhibidores selectivos de recaptación de serotonina en síntomas no cognitivos del alzhéimer: revisión sistemáticaspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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