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CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba

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dc.creatorKour, Vivian
dc.creatorKhouri, Ricardo
dc.creatorAlemán, Yoan
dc.creatorAbrahantes, Yeissel
dc.creatorVercauteren, Jurgen
dc.creatorPineda-Peña, Andrea-Clemencia
dc.creatorTheys, Kristof
dc.creatorMegens, Sarah
dc.creatorMoutschen, Michel
dc.creatorPfeifer, Nico
dc.creatorVan Weyenbergh, Johan
dc.creatorPérez, Ana B.
dc.creatorPérez, Jorge
dc.creatorPérez, Lissette
dc.creatorVan Laethem, Kristel
dc.creatorVandamme, Anne-Mieke
dc.creator.googleKour, Vivianspa
dc.creator.googleKhouri, Ricardo
dc.creator.googleAlemán, Yoan
dc.creator.googleAbrahantes, Yeissel
dc.creator.googleVercauteren, Jurgen
dc.creator.googlePineda-Peña, Andrea-Clemencia
dc.creator.googleTheys, Kristof
dc.creator.googleMegens, Sarah
dc.creator.googleMoutschen, Michel
dc.creator.googlePfeifer, Nico
dc.creator.googleVan Weyenbergh, Johan
dc.creator.googlePérez, Ana B.
dc.creator.googlePérez, Jorge
dc.creator.googlePérez, Lissette
dc.creator.googleVan Laethem, Kristel
dc.creator.googleVandamme, Anne-Mieke
dc.date.accessioned2019-02-12T17:47:19Z
dc.date.available2019-02-12T17:47:19Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractBackground: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3. years of infection) in Cuba. Methods: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as >. 3. years infected. Clinical, demographic, virological, epidemiological and immunological data were collected. Pol and env sequences were used for subtyping, transmission cluster analysis, and prediction of resistance, co-receptor use and evolutionary fitness. Host, immunological and viral predictors of RP were explored through data mining. Findings: Subtyping revealed 26 subtype B strains, 6 C, 6 CRF18_cpx, 9 CRF19_cpx, 29 BG-recombinants and other subtypes/URFs. All patients infected with CRF19 belonged to the AIDS-RP group. Data mining identified CRF19, oral candidiasis and RANTES levels as the strongest predictors of AIDS-RP. CRF19 was more frequently predicted to use the CXCR4 co-receptor, had higher fitness scores in the protease region, and patients had higher viral load at diagnosis. Interpretation: CRF19 is a recombinant of subtype D (C-part of Gag, PR, RT and nef), subtype A (N-part of Gag, Integrase, Env) and subtype G (Vif, Vpr, Vpu and C-part of Env). Since subtypes D and A have been associated with respectively faster and slower disease progression, our findings might indicate a fit PR driving high viral load, which in combination with co-infections may boost RANTES levels and thus CXCR4 use, potentially explaining the fast progression. We propose that CRF19 is evolutionary very fit and causing rapid progression to AIDS in many newly infected patients in Cuba. © 2015.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn23523964
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19047
dc.language.isoengspa
dc.relation.citationEndPage254
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage244
dc.relation.citationTitleEBioMedicine
dc.relation.citationVolumeVol. 2
dc.relation.ispartofEBioMedicine, ISSN: 2352-3964, Vol. 2/No. 3 (2015) pp. 244-254spa
dc.relation.urihttps://ac.els-cdn.com/S2352396415000389/1-s2.0-S2352396415000389-main.pdf?_tid=82a94548-bad7-4869-adc8-943d5601430b&acdnat=1540056579_daab21c266910bdc445f9fd338362f4espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.source.bibliographicCitationAbrahantes Rodríguez, Y., Pérez Avila, J., Kouri Cardellá, V., Fonseca Gómez, C., Baly Gil, A., Tápanes Fernandez, T., Factors linked to rapid progression to AIDS in Cuban subjects (2010) Rev. Cubana Med. Trop., 62, pp. 146-153spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCrf19spa
dc.subjectCubaspa
dc.subjectHiv-1spa
dc.subjectProgression To Aidsspa
dc.subjectVariantspa
dc.subject.ddcGrupos socialesspa
dc.subject.decsAlpha Interferonspa
dc.subject.decsBeta 2 Microglobulinspa
dc.subject.decsChemokine Receptor Ccr5spa
dc.subject.decsChemokine Receptor Cxcr4spa
dc.subject.decsCxcl9 Chemokinespa
dc.subject.decsFas Ligandspa
dc.subject.decsGamma Interferonspa
dc.subject.decsGamma Interferon Inducible Protein 1spa
dc.subject.decsGranulocyte Colony Stimulating Factorspa
dc.subject.decsInterleukin 1spa
dc.subject.decsInterleukin 12P7spa
dc.subject.decsInterleukin 1Betaspa
dc.subject.decsInterleukin 2spa
dc.subject.decsInterleukin 4spa
dc.subject.decsInterleukin 5spa
dc.subject.decsInterleukin 6spa
dc.subject.decsInterleukin 8spa
dc.subject.decsLymphotoxinspa
dc.subject.decsMacrophage Inflammatory Protein 1Alphaspa
dc.subject.decsMacrophage Inflammatory Protein 1Betaspa
dc.subject.decsMonocyte Chemotactic Protein 1spa
dc.subject.decsNeopterinspa
dc.subject.decsRantesspa
dc.subject.decsTumor Necrosis Factor Alphaspa
dc.subject.decsPol Proteinspa
dc.subject.decsVirus Envelope Proteinspa
dc.subject.decsAcquired Immune Deficiency Syndromespa
dc.subject.decsAdultspa
dc.subject.decsAntiviral Resistancespa
dc.subject.decsArticlespa
dc.subject.decsCd4 Lymphocyte Countspa
dc.subject.decsControlled Studyspa
dc.subject.decsCubaspa
dc.subject.decsDisease Coursespa
dc.subject.decsEnzyme Linked Immunosorbent Assayspa
dc.subject.decsFemalespa
dc.subject.decsGenetic Analysisspa
dc.subject.decsGenetic Variabilityspa
dc.subject.decsHeterosexualityspa
dc.subject.decsHumanspa
dc.subject.decsHuman Immunodeficiency Virus 1 Infectionspa
dc.subject.decsImmunityspa
dc.subject.decsMajor Clinical Studyspa
dc.subject.decsMalespa
dc.subject.decsMixed Infectionspa
dc.subject.decsPriority Journalspa
dc.subject.decsProspective Studyspa
dc.subject.decsReproductive Fitnessspa
dc.subject.decsRetrospective Studyspa
dc.subject.decsThrushspa
dc.subject.decsVirus Loadspa
dc.subject.decsVirus Recombinationspa
dc.subject.decsVirus Replicationspa
dc.subject.decsVirus Transmissionspa
dc.subject.decsVirus Typingspa
dc.subject.decsYoung Adultspa
dc.subject.decsAcquired Immunodeficiency Syndromespa
dc.subject.decsDrug Effectsspa
dc.subject.decsEvolutionspa
dc.subject.decsGenetic Variationspa
dc.subject.decsGeneticsspa
dc.subject.decsHiv Infectionsspa
dc.subject.decsHuman Immunodeficiency Virus 1spa
dc.subject.decsImmunologyspa
dc.subject.decsPathogenicityspa
dc.subject.decsSexual Behaviorspa
dc.subject.decsVirologyspa
dc.subject.decsAcquired Immunodeficiency Syndromespa
dc.subject.decsAdultspa
dc.subject.decsBiological Evolutionspa
dc.subject.decsCoinfectionspa
dc.subject.decsCubaspa
dc.subject.decsDrug Resistance, Viralspa
dc.subject.decsEnv Gene Products, Human Immunodeficiency Virusspa
dc.subject.decsFemalespa
dc.subject.decsGenetic Variationspa
dc.subject.decsHiv Infectionsspa
dc.subject.decsHiv-1spa
dc.subject.decsHumansspa
dc.subject.decsMalespa
dc.subject.decsPol Gene Products, Human Immunodeficiency Virusspa
dc.subject.decsRetrospective Studiesspa
dc.subject.decsSexual Behaviorspa
dc.subject.decsViral Loadspa
dc.subject.decsYoung Adultspa
dc.subject.lembEnfermedad del sidaspa
dc.subject.lembPersonas VIH positivasspa
dc.titleCRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cubaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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