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Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort

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dc.creatorRasmussen, Astridspa
dc.creatorIce, John Aspa
dc.creatorLi, Hespa
dc.creatorGrundahl, Kielyspa
dc.creatorKelly, Jennifer Aspa
dc.creatorRadfar, Lidaspa
dc.creatorStone, Donald Uspa
dc.creatorHefner, Kimberly Sspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorRohrer, Michaelspa
dc.creatorGopalakrishnan, Rajaramspa
dc.creatorHouston, Glen Dspa
dc.creatorLewis, David Mspa
dc.creatorChodosh, Jamesspa
dc.creatorHarley, John Bspa
dc.creatorHughes, Pamelaspa
dc.creatorMaier-Moore, Jacen Sspa
dc.creatorMontgomery, Courtney Gspa
dc.creatorRhodus, Nelson Lspa
dc.creatorFarris, A Darisespa
dc.creatorSegal, Barbara Mspa
dc.creatorJonsson, Rolandspa
dc.creatorLessard, Christopher Jspa
dc.creatorScofield, R Halspa
dc.creatorSivils, Kathy L Moserspa
dc.date.accessioned2020-05-25T23:56:28Z
dc.date.available2020-05-25T23:56:28Z
dc.date.created2014spa
dc.description.abstractObjective To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. Methods In a multidisciplinary clinic for the evaluation of sicca, we assessed features of salivary and lacrimal gland dysfunction and autoimmunity as defined by tests of both AECG and ACR criteria in 646 participants. Global gene expression profiles were compared in a subset of 180 participants. Results Application of the AECG and ACR criteria resulted in classification of 279 and 268 participants with SS, respectively. Both criteria were met by 244 participants (81%). In 26 of the 35 AECG+/ACR participants, the minor salivary gland biopsy focal score was ?1 (74%), while nine had positive anti-Ro/La (26%). There were 24 AECG-/ACR+ who met ACR criteria mainly due to differences in the scoring of corneal staining. All patients with SS, regardless of classification, had similar gene expression profiles, which were distinct from the healthy controls. Conclusions The two sets of classification criteria yield concordant results in the majority of cases and gene expression profiling suggests that patients meeting either set of criteria are more similar to other SS participants than to healthy controls. Thus, there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective. It is our contention, supported by this report, that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/annrheumdis-2013-203845
dc.identifier.issn00034967
dc.identifier.issn14682060
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22433
dc.language.isoengspa
dc.relation.citationEndPage38
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage31
dc.relation.citationTitleAnnals of the Rheumatic Diseases
dc.relation.citationVolumeVol. 73
dc.relation.ispartofAnnals of the Rheumatic Diseases, ISSN:00034967, 14682060, Vol.73, No.1 (2014); pp. 31-38spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84889637008&doi=10.1136%2fannrheumdis-2013-203845&partnerID=40&md5=b2e701d30c065306b01c6f92581f2c1cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmerical European consensus groupspa
dc.subject.keywordAmerican college of rheumatologyspa
dc.subject.keywordClinical featurespa
dc.subject.keywordComparative studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiagnostic test accuracy studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDisease classificationspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordLacrimal gland diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMedical societyspa
dc.subject.keywordOrganizational developmentspa
dc.subject.keywordOrganizational downsizingspa
dc.subject.keywordOrganizational efficiencyspa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPredictive valuespa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSalivary gland biopsyspa
dc.subject.keywordSalivary gland diseasespa
dc.subject.keywordScoring systemspa
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordClassificationspa
dc.subject.keywordDiagnosisspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordCohort Studiesspa
dc.subject.keywordConsensusspa
dc.subject.keywordEuropespa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordTranscriptomespa
dc.subject.keywordUnited Statesspa
dc.subject.keywordYoung Adultspa
dc.titleComparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohortspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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