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Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.

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dc.creatorCruz-Tapias, Paolaspa
dc.creatorPerez-Fernandez, Oscar Mspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorRodriguez-Rodriguez, Albertospa
dc.creatorArango, Maria-Teresaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-08-06T16:21:33Z
dc.date.available2020-08-06T16:21:33Z
dc.date.created2012spa
dc.description.abstractThe prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95%CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2012/569728
dc.identifier.issnISSN: 20900422
dc.identifier.issnEISSN: 2090-0430
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26395
dc.language.isoengspa
dc.publisherHindawi Publishing Corporationspa
dc.relation.citationEndPage728
dc.relation.citationStartPage569
dc.relation.citationTitleAutoimmune diseases
dc.relation.citationVolumeVol. 2012
dc.relation.ispartofAutoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.569-728spa
dc.relation.urihttp://downloads.hindawi.com/journals/ad/2012/569728.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceAutoimmune diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordautoimmune diseasesspa
dc.subject.keywordlatitudinal gradientspa
dc.subject.keywordsystemic lupus erythematosusspa
dc.titleShared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.spa
dc.title.TranslatedTitleHLA compartida clase II en seis enfermedades autoinmunes en América Latina: un metanálisis.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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