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Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red

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dc.contributor.advisorBuitrago Medina, Daniel Alejandro
dc.contributor.advisorÁlvarez Sierra, Julián Leonardo
dc.creatorSandoval Vásquez, Ricardo Augusto
dc.creatorSuarez Carvajal, Dayana Carolina
dc.creatorValdivieso Rolleri, María Augusta
dc.creator.degreeEspecialista en Medicina Estéticaspa
dc.creator.degreetypeFull timespa
dc.date.accessioned2019-01-17T12:41:24Z
dc.date.available2019-01-17T12:41:24Z
dc.date.created2018-12-13
dc.date.issued2018
dc.descriptionAntecedentes: Liraglutida es un medicamento potencialmente útil en el tratamiento farmacológico de sobrepeso y obesidad, sin embargo, no ha sido evaluada de forma sistemática, ni su relación frente a otras terapias actualmente utilizadas; por lo que el objetivo de este estudio es valorar su eficacia comparada contra otros medicamentos, en la reducción de peso corporal. Metodología: Se realizó una revisión sistemática y meta-análisis en red, para la búsqueda se utilizaron las bases de datos Medline, Embase y LiLaCS; se incluyeron ensayos clínicos controlados en inglés y español, concluyendo con un análisis cualitativo y cuantitativo de la información. Resultados: Se incluyeron 20 estudios. De acuerdo al análisis de la comparación directa contra placebo, la liraglutida logró una pérdida de peso de hasta 5 kg en 6 meses (diferencia de promedios -5.28 [-5.49, -5.07]) y contra orlistat, demostró una mayor proporción de pacientes con pérdida del 5% o más del peso corporal (OR 4.02 [2.14, 7.52]). En la comparación indirecta, lorcaserina OR 3,77 (IC95% 3,17 ;4,44) y topiramato/fentermina OR 2,03 (IC95% 1,65; 2,55) mostraron una mayor proporción de pacientes con pérdida de peso del 5% o más. Las reacciones adversas no severas fueron superiores con liraglutida en relación con el resto de terapias farmacológicas exceptuando naltrexona/bupropion. Conclusión: La liraglutida es una opción farmacológica eficaz para el tratamiento de sobrepeso y obesidad. El análisis directo muestra superioridad frente a placebo y orlistat. La comparación indirecta muestra que es inferior a topiramato/fentermina y lorcaserina pero superior a metformina, exenatide, bupropión y naltrexona/bupropion.spa
dc.description.abstractBackground: Liraglutide is a drug that may be useful in the pharmacological treatment of overweight and obesity, however, its effectiveness has not been evaluated systematically or its relationship with other drugs, so the objective of this study is to evaluate its effectiveness in comparison with other currently available management therapies in body weight reduction. Methodology: A systematic review and network meta-analysis were carried out. For the search, Medline, Embase and LiLaCS databases were used and controlled clinical trials published in English and Spanish were included, performing a qualitative and quantitative analysis of the information. Results: Twenty studies were included. According to the analysis of the direct comparison against placebo, Liraglutide achieved a weight loss of up to 5 kg in 6 months (mean difference -5.28 [-5.49, -5.07]) and against Orlistat, showed a higher proportion of patients with loss of 5% or more of body weight (OR 4.02 [2.14, 7.52]). In the indirect comparison, Lorcaserin OR 3.77 (95% CI 3.17, 4.44) and Topiramate / Phentermine OR 2.03 (95% CI 1.65, 2.55) showed a higher proportion of patients with loss of weight of 5% or more. The proportion of non-severe adverse reactions was higher with Liraglutide compared to the rest of the pharmacological therapies except Naltrexone / Bupropion. Conclusion: Liraglutide is an effective pharmacological option for the treatment of overweight/obesity. The direct analysis shows superiority against placebo and Orlistat. Indirect comparison shows that it is inferior to Topiramate / Phentermine and Lorcaserin, and superior to Metformin, Exenatide, Bupropion and Naltrexone / Bupropion.spa
dc.description.embargo2021-01-25 01:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2021-01-25spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_18879
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18879
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Medicina Estética y laserspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectObesidadspa
dc.subjectAgentes antiobesidadspa
dc.subjectLiraglutidaspa
dc.subjectPérdida de pesospa
dc.subjectMeta-análisis en redspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordObesityspa
dc.subject.keywordAnti-obesity agentsspa
dc.subject.keywordLiraglutidespa
dc.subject.keywordWeight lossspa
dc.subject.keywordMeta-analysis in the networkspa
dc.subject.lembObesidadspa
dc.subject.lembLiraglutidaspa
dc.titleEficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en redspa
dc.typemasterThesiseng
dc.type.documentMeta-análisisspa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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Especialización en Medicina Estética y Laser