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Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

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dc.creatorMamtani M.spa
dc.creatorMummidi S.spa
dc.creatorRamsuran V.spa
dc.creatorPham M.-H.spa
dc.creatorMaldonado R.spa
dc.creatorBegum K.spa
dc.creatorValera M.S.spa
dc.creatorSanchez R.spa
dc.creatorCastiblanco J.spa
dc.creatorKulkarni H.spa
dc.creatorNdung'u T.spa
dc.creatorHe W.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorAhuja S.K.spa
dc.date.accessioned2020-05-25T23:56:15Z
dc.date.available2020-05-25T23:56:15Z
dc.date.created2011spa
dc.description.abstractWe investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jir145
dc.identifier.issn00221899
dc.identifier.issn15376613
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22374
dc.language.isoengspa
dc.relation.citationEndPage1594
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage1590
dc.relation.citationTitleJournal of Infectious Diseases
dc.relation.citationVolumeVol. 203
dc.relation.ispartofJournal of Infectious Diseases, ISSN:00221899, 15376613, Vol.203, No.11 (2011); pp. 1590-1594spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79956196408&doi=10.1093%2finfdis%2fjir145&partnerID=40&md5=b6947bee29637642fcbbca494bd38f79spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCCL3L1 chemokinespa
dc.subject.keywordCCR5eng
dc.subject.keywordGeneticeng
dc.subject.keywordChemokinespa
dc.subject.keywordCCeng
dc.subject.keywordChemokine receptor CCR5spa
dc.subject.keywordMacrophage inflammatory protein 1alphaspa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordVirus receptorspa
dc.subject.keywordAcquired immune deficiency syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCCR5 genespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordGenespa
dc.subject.keywordGene dosagespa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordTuberculosisspa
dc.subject.keywordAdultspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordChemokineseng
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Dosagespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHumansspa
dc.subject.keywordLinkage Disequilibriumspa
dc.subject.keywordLogistic Modelsspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.subject.keywordTuberculosisspa
dc.titleInfluence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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