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Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children

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dc.contributor.gruplacBio-Biospa
dc.creatorNarvaez-Sanchez, Raul
dc.creatorGonzalez, Luz
dc.creatorSalamanca-Matta, Alba Lucía
dc.creatorSilva, Myriam
dc.creatorRios-Chaparro, Dora-Ines
dc.creatorArevalo, Sinay
dc.creatorGastelbondo Amaya, Ricardo
dc.creatorSanchez, Javier
dc.creator.googleLuz Stella Gonzalez, Myriam Silva, Dora Rios, Sinay Arevalo, Ricardo Gastelbondo, Alba Lucía Salamanca Matta, Narvaez Sanchez-Sanchez, Raul
dc.creator.googleRios Chaparro, Dora Ines
dc.creator.googleArevalo Leal, Sinay
dc.creator.googleNarvaez, Raul
dc.creator.googleGastelbondo Amaya, Ricardo
dc.date.accessioned2018-08-30T15:50:53Z
dc.date.available2018-08-30T15:50:53Z
dc.date.created2008
dc.date.issued2008
dc.description.abstractBackground: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (ClTc) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD. Methods: Data were collected from 109 Colombian outpatients aged less than 18 years referred for determination of GFR because of suspected or definite renal insufficiency. The cost of each test was determined in Bogotá, Colombia, and in Madrid, Spain. Results: Using a GFR of 90 mL/min as a cut-off value, we found: CysC sensitivity 75%, specificity 84%, and area under ROC curve (AUC) 0.84. SCr sensitivity 46%, specificity 100%, and AUC 0.72. Using a GFR of 70 mL/min as a cut-off value, we found: CysC sensitivity 100%, specificity 48%, and AUC 0.94. SCr sensitivity 77%, specificity 91%, and AUC 0.81. In all calculations predictive values behave correspondingly and ranges were narrow at CI 95%. In AUC, p = 0.0001. Cost per enzymatic test in Bogotá: CysC U$ 27; SCr U$ 2. Cost per enzymatic test in Madrid: CysC U$ 3; SCr U$ 0.08. Conclusion: CysC is a very interesting option, and could be a replacement to serum creatinine for diagnosing and possibly for monitoring kidney function in children.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0009-9120
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18424
dc.language.isoengspa
dc.relation.citationEndPage503
dc.relation.citationIssueNo. 41
dc.relation.citationStartPage498
dc.relation.citationTitleClinical Biochemistry
dc.relation.ispartofClinical Biochemistry, ISSN 0009-9120, No. 41, (2008); pp. 498–503spa
dc.relation.urihttps://www.elsevier.com/journals/clinical-biochemistry/0009-9120/open-access-optionsspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttps://ac.els-cdn.com/S0009912008000519/1-s2.0-S0009912008000519-main.pdf?_tid=5c154ea4-ba61-11e7-8cc7-00000aacb362&acdnat=1509031478_89757a5d0c4937671de2768438e29747
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSensitivity and specificityspa
dc.subject.keywordGlomerular filtration ratespa
dc.subject.keywordCreatininespa
dc.subject.keywordCystatinsspa
dc.subject.lembInsuficiencia Renal Crónicaspa
dc.subject.lembTasa de Filtración Glomerularspa
dc.subject.lembCreatininaspa
dc.titleCystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in childrenspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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