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Peptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates?

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dc.creatorPatarroyo, Manuel A.spa
dc.creatorCurtidor, Hernandospa
dc.creatorPlaza, David F.spa
dc.creatorOcampo, Marisol
dc.creatorReyes, Claudiaspa
dc.creatorSaboya, Obeimarspa
dc.creatorBarrera, Gloriaspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:02:04Z
dc.date.available2020-05-26T00:02:04Z
dc.date.created2008spa
dc.description.abstractThis study reports the Rv1490 gene presence and transcription in members of the Mycobacterium tuberculosis complex, and characterises the encoded Rv1490 putative membrane protein in M. tuberculosis H37Rv. Rv1490 derived peptides were synthesised and their A549 and U937 cell binding ability was tested, finding five high activity binding peptides (HABPs) for A549 and five for U937. Only two HABPs (11060 and 11073) were shared by both cell lines, both of which affected M. tuberculosis' invading ability to target cells, thus indicating an important role for these sequences in M. tuberculosis entry to A549 alveolar epithelial cells and supporting their inclusion in further studies on the development of a subunit-based multi-epitopic, chemically synthesised anti-tuberculosis vaccine. © 2008 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2008.05.092
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23446
dc.language.isoengspa
dc.relation.citationEndPage4395
dc.relation.citationIssueNo. 34
dc.relation.citationStartPage4387
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 26
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.26, No.34 (2008); pp. 4387-4395spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-47649132993&doi=10.1016%2fj.vaccine.2008.05.092&partnerID=40&md5=42f62e877e36c3c4e3846410ec1582e8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordelectroneng
dc.subject.keywordtransmissioneng
dc.subject.keywordArticlespa
dc.subject.keywordBacterial genespa
dc.subject.keywordCell linespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEpithelium cellspa
dc.subject.keywordGenetic transcriptionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordImmunoelectron microscopyspa
dc.subject.keywordLung alveolus epitheliumspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPeptide synthesisspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein localizationspa
dc.subject.keywordRv1490 genespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordBacterial adhesionspa
dc.subject.keywordBacterial proteinsspa
dc.subject.keywordCell linespa
dc.subject.keywordEpithelial cellsspa
dc.subject.keywordMembrane proteinsspa
dc.subject.keywordMicroscopyeng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordPeptidesspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordRabbitsspa
dc.subject.keywordRv1490spa
dc.subject.keywordTuberculosisspa
dc.subject.keywordVaccinesspa
dc.titlePeptides derived from the Mycobacterium tuberculosis Rv1490 surface protein implicated in inhibition of epithelial cell entry: Potential vaccine candidates?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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