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Drivers of HIV-1 transmission: The Portuguese case

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dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorPingarilho, Martaspa
dc.creatorLi, Guangdispa
dc.creatorVrancken, Bramspa
dc.creatorLibin, Pieterspa
dc.creatorGomes, Perpétuaspa
dc.creatorCamacho, Ricardo Jorgespa
dc.creatorTheys, Kristofspa
dc.creatorAbecasis, Ana Barrosospa
dc.date.accessioned2020-05-25T23:58:18Z
dc.date.available2020-05-25T23:58:18Z
dc.date.created2019spa
dc.description.abstractBackground Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. Methods Demographic, clinical and genomic data were collected from 3599 HIV-1 naive patients between 2001 and 2014. Sequences obtained from drug resistance testing were used for subtyping, TDR determination and transmission clusters (TC) analyses. Results In Portugal, transmission of subtype B was significantly associated with young males, while transmission of subtype G was associated with older heterosexuals. In Portuguese originated people, there was a decreasing trend both for prevalence of subtype G and for number of TCs in this subtype. The active TCs that were identified (i.e. clusters originated after 2008) were associated with subtype B-infected males residing in Lisbon. TDR was significantly different when comparing subtypes B (10.8% [9.5–12.2]) and G (7.6% [6.4–9.0]) (p = 0.001). Discussion TC analyses shows that, in Portugal, the subtype B epidemic is active and fueled by young male patients residing in Lisbon, while transmission of subtype G is decreasing. Despite similar treatment rates for both subtypes in Portugal, TDR is significantly different between subtypes. © 2019 Pineda-Peña et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0218226
dc.identifier.issn19326203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22836
dc.language.isoengspa
dc.publisherPublic Library of Sciencespa
dc.relation.citationIssueNo. 9
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 14
dc.relation.ispartofPLoS ONE, ISSN:19326203, Vol.14, No.9 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072733890&doi=10.1371%2fjournal.pone.0218226&partnerID=40&md5=3e17f0f925edacb6c422c58435cc3547spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHuman immunodeficiency virus proteinase inhibitorspa
dc.subject.keywordHighly Activeeng
dc.subject.keywordRNA directed DNA polymerase inhibitorspa
dc.subject.keywordAdultspa
dc.subject.keywordAgespa
dc.subject.keywordAntiviral resistancespa
dc.subject.keywordArticlespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemographyspa
dc.subject.keywordEpidemicspa
dc.subject.keywordFemalespa
dc.subject.keywordGenomicsspa
dc.subject.keywordHeterosexualityspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1 infectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPortugalspa
dc.subject.keywordPortuguese (citizen)spa
dc.subject.keywordPrevalencespa
dc.subject.keywordSex differencespa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordDrug effectspa
dc.subject.keywordFollow upspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordHealth surveyspa
dc.subject.keywordHighly active antiretroviral therapyspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordSex factorspa
dc.subject.keywordSocioeconomicsspa
dc.subject.keywordVirologyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAge Factorsspa
dc.subject.keywordAntiretroviral Therapyeng
dc.subject.keywordDrug Resistanceeng
dc.subject.keywordFemalespa
dc.subject.keywordFollow-Up Studiesspa
dc.subject.keywordGenotypespa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordOdds Ratiospa
dc.subject.keywordPortugalspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPublic Health Surveillancespa
dc.subject.keywordSex Factorsspa
dc.subject.keywordSocioeconomic Factorsspa
dc.subject.keywordYoung Adultspa
dc.titleDrivers of HIV-1 transmission: The Portuguese casespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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