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Genetics and vaccines in the era of personalized medicine

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dc.creatorCastiblanco, Johnspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:05:35Z
dc.date.available2020-05-26T00:05:35Z
dc.date.created2015spa
dc.description.abstractVaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach. ©2015 Bentham Science Publishers.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1389202916666141223220551
dc.identifier.issn13892029
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23806
dc.language.isoengspa
dc.publisherBentham Science Publishers B.V.spa
dc.relation.citationEndPage59
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage47
dc.relation.citationTitleCurrent Genomics
dc.relation.citationVolumeVol. 16
dc.relation.ispartofCurrent Genomics, ISSN:13892029, Vol.16, No.1 (2015); pp. 47-59spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84926287802&doi=10.2174%2f1389202916666141223220551&partnerID=40&md5=8b7de78028c96f9638ecd7f41b61ef8espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCD45 antigenspa
dc.subject.keywordCell surface receptorspa
dc.subject.keywordCytokinespa
dc.subject.keywordHepatitis B vaccinespa
dc.subject.keywordInfluenza vaccinespa
dc.subject.keywordMeasles mumps rubella vaccinespa
dc.subject.keywordPoliomyelitis vaccinespa
dc.subject.keywordRabies vaccinespa
dc.subject.keywordToll like receptorspa
dc.subject.keywordVaccinespa
dc.subject.keywordVaccinia vaccinespa
dc.subject.keywordAllelespa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordDNA modificationspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordDrug designspa
dc.subject.keywordGene functionspa
dc.subject.keywordGene interactionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHeredityspa
dc.subject.keywordHLA systemspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunizationspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordPersonalized medicinespa
dc.subject.keywordSmallpoxspa
dc.subject.keywordStreptococcus agalactiaespa
dc.subject.keywordStreptococcus group Aspa
dc.subject.keywordAutoimmune ecologyspa
dc.subject.keywordAutoimmunity and systems biologyspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHLAspa
dc.subject.keywordInfectionspa
dc.subject.keywordPersonalized medicinespa
dc.subject.keywordVaccinespa
dc.titleGenetics and vaccines in the era of personalized medicinespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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