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ECLAMC study : Prevalence patterns of hypospadias in South America : Multi-national analysis over a 24-year period

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dc.creatorFernández, Nicolás
dc.creatorPérez, Jaime
dc.creatorMonterrey, Pedro
dc.creatorPoletta, Fernando A.
dc.creatorBägli, Darius J.
dc.creatorLorenzo, Armando J.
dc.creatorZarante, Ignacio
dc.creator.googleFernández, Nicolásspa
dc.creator.googlePérez, Jaimespa
dc.creator.googleMonterrey, Pedrospa
dc.creator.googlePoletta, Fernando A.spa
dc.creator.googleBägli, Dariusspa
dc.creator.googleLorenzo, Armando J.spa
dc.creator.googleZarante, Ignaciospa
dc.date.accessioned2020-05-12T10:12:53Z
dc.date.available2020-05-12T10:12:53Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractObjective: To evaluate prevalence trends of hypospadias in South-America it is essential to perform multicenter and multinational studies with the same methodology. Herein we present systematic data as part of an international multicenter initiative evaluating congenital malformations in South America over a 24-year period. Materials and Methods: A nested case-control study was conducted using the Latin American Collaborative Study of Congenital Malformations (ECLAMC), between January 1989 and December 2012. Cases were stratified as isolated (IH) and non-isolated hypospadias (NIH). Global prevalence was calculated and discriminated by country. Associations between birth weight and gestational age, and NIH distribution by associated abnormality and severity of hypospadias, were analyzed. Results: A total of 159 hospitals from six countries participated, reporting surveillance on 4.020.384 newborns. A total of 4.537 hypospadias cases were detected, with a global prevalence of 11.3/10.000 newborns. Trend analyses showed in Chile, Brazil and Uruguay a statistically significant increase in prevalence. Analysis of severity and associated anomalies did not to find an association for distal cases, but did for proximal (RR=1.64 [95% CI=1.33-2.03]). Conclusion: This is one of only a few Latin American multicenter studies reporting on the epidemiology of hypospadias in South America in the last two decades. Our data adds to evidence suggesting an increase in some countries in the region at different times. There were also variations in prevalence according to severity. This study adds to literature describing associated anomalies at a hospital-based level.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1590/S1677-5538.IBJU.2016.0002
dc.identifier.issn1677-5538
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21975
dc.language.isoengspa
dc.relation.citationEndPage334
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage325
dc.relation.citationTitleInternational Braz J Urol
dc.relation.citationVolumeVol. 43
dc.relation.ispartofInternational Braz J Urol, ISSN: 1677-5538 Vol. 43, No. 2 (2017) pp. 325-334spa
dc.relation.urihttp://www.scielo.br/pdf/ibju/v43n2/1677-5538-ibju-43-02-0325.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.keywordHypospadiasspa
dc.subject.keywordPrevalencespa
dc.subject.keywordEpidemiologyspa
dc.titleECLAMC study : Prevalence patterns of hypospadias in South America : Multi-national analysis over a 24-year periodspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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