The autoimmune tautology: an in silico approach.

Cifuentes, Ricardo A; Restrepo-Montoya, Daniel; Anaya, Juan-Manuel

doi:https://doi.org/10.1155/2012/792106

Ítem

Acceso Abierto

The autoimmune tautology: an in silico approach.

Mostrar el registro sencillo de la publicación

dc.creator	Cifuentes, Ricardo A	spa
dc.creator	Restrepo-Montoya, Daniel	spa
dc.creator	Anaya, Juan-Manuel	spa
dc.date.accessioned	2020-08-06T16:20:11Z
dc.date.available	2020-08-06T16:20:11Z
dc.date.created	2012	spa
dc.description.abstract	There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sjogren's syndrome-systemic lupus erythematosus, and autoimmune thyroid disease-type1 diabetes-rheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10.	eng
dc.format.mimetype	application/pdf
dc.identifier.doi	https://doi.org/10.1155/2012/792106
dc.identifier.issn	ISSN: 20900422
dc.identifier.issn	EISSN: 2090-0430
dc.identifier.uri	https://repository.urosario.edu.co/handle/10336/25908
dc.language.iso	eng	spa
dc.publisher	Hindawi Publishing Corporation	spa
dc.relation.citationStartPage	10
dc.relation.citationTitle	Autoimmune diseases
dc.relation.ispartof	Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430 (2012); pp.10	spa
dc.relation.uri	http://downloads.hindawi.com/journals/ad/2012/792106.pdf	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto Completo)	spa
dc.source	Autoimmune diseases	spa
dc.source.instname	instname:Universidad del Rosario
dc.source.reponame	reponame:Repositorio Institucional EdocUR
dc.subject.keyword	Genetic	spa
dc.subject.keyword	Autoimmune diseases	spa
dc.subject.keyword	Diabetes rheumatoid	spa
dc.subject.keyword	Arthritis	spa
dc.title	The autoimmune tautology: an in silico approach.	spa
dc.title.TranslatedTitle	La tautología autoinmune: un enfoque in silico.	eng
dc.type	article	eng
dc.type.hasVersion	info:eu-repo/semantics/publishedVersion
dc.type.spa	Artículo	spa