Ítem
Acceso Abierto
Comparación entre pacientes con Candidemia causada por Candida Albicans versus Candida No-albicans en una población de adultos Fundación Cardio-Infantil, Bogotá, Colombia periodo 2012-2017
dc.contributor | Marín, Víctor | |
dc.contributor.advisor | Castañeda Luquerna, Aurora Ximena | |
dc.creator | Herrera Díaz, Ana Catalina | |
dc.creator.degree | Especialista en Infectología | spa |
dc.creator.degreetype | Full time | spa |
dc.date.accessioned | 2019-01-29T15:08:35Z | |
dc.date.available | 2019-01-29T15:08:35Z | |
dc.date.created | 2018-11-07 | |
dc.date.issued | 2018 | |
dc.description | Introducción. La candidemia es la infección fúngica intrahospitalaria más frecuente alrededor del mundo. Dentro de las especies principales‚ la C. albicans ha sido la más común; sin embargo‚ han surgido especies no albicans (ENA) asociadas con factores específicos y peores desenlaces clínicos, así como mortalidad más elevada. Materiales y métodos. Estudio analítico retrospectivo de corte transversal de pacientes adultos con candidemia entre 2012 a 2017. Se compararon los grupos de candidemia por C. albicans y no albicans. Resultados. Se confirmaron 79 episodios de candidemia. La mayoría fueron hombres (60‚7%)‚ con edad promedio de 58 años /21. Predominaron las ENA (63‚3% vs 36‚7% P 0‚001 IC 95% 0‚001-0‚003) ‚ C. glabrata (20‚3%)‚ C. tropicalis (15.2%)‚ C. parapsilosis (10‚1%) y C. krusei (8‚9%). La mortalidad fue más alta en ENA (48 vs 61%). El 54‚4% de los pacientes tuvieron bacteriemia concomitante. C. albicans fue sensible a fluconazol en un 96‚5%. La sensibilidad de las ENA fue de 80% a fluconazol‚ 12% resistentes. La nutrición parenteral total (NPT) se asoció con candidemia por C. albicans (OR 2‚19 IC 95% 1‚1-4‚3‚ P 0‚023) y la presencia de comorbilidad pulmonar (CP) con candidemia por ENA (OR 5‚6 IC 95% 1‚6-20 P 0‚007). Conclusiones. Durante el periodo evaluado de 6 años, las especies que predominan en los episodios de candidemia son especies no-albicans con una mortalidad más elevada. La NPT favorece la C. albicans mientras que la CP se asocia con ENA. | spa |
dc.description.abstract | Introduction. Candidemia is the most common hospital acquired fungal infection around the world. While C. albicans has been the most common species; non-albicans (NAS) species have emerged and have been associated with specific factors and poorer clinical outcomes, as well as higher mortality. Materials and methods. Retrospective analytical cross-sectional study of adult patients with candidemia between 2012 to 2017 at Fundación CardioInfantil in Bogotá, Colombia. Candidemia groups were compared by C. albicans and nonalbicans. Results. 79 episodes of candidemia were confirmed and identified. The majority were men (60.7%), with an average age of 58 years / 21. NAS predominated (63.3% vs 36.7% P 0.001 IC 95% 0.001-0.003), C. glabrata (20.3%), C. tropicalis (15.2%), C. parapsilosis (10.1%) and C. krusei (8.9%). Mortality was higher in NAS (48 vs 61%). 54.4% of the patients had concomitant bacteremia. C. albicans was sensitive to fluconazole in 96.5%. The sensitivity of the ENA was 80% to fluconazole, 12% resistant. Total parenteral nutrition (TPN) was associated with candidemia due to C. albicans (OR 2.19 IC 95% 1.1-4.3, P 0.023) and the presence of pulmonary comorbidity (COP) with candidemia due to NAS (OR 5.6 IC 95% 1.6-20 P 0.007). Conclusions. At Fundación CardioInfantil and during an observation period of six years, candidemia by NAS predominates with a higher mortality on non albicans species. The NPT favors C. albicans while the CP is associated with ENA. | spa |
dc.format.mimetype | application/pdf | |
dc.identifier.doi | https://doi.org/10.48713/10336_18950 | |
dc.identifier.uri | http://repository.urosario.edu.co/handle/10336/18950 | |
dc.language.iso | spa | |
dc.publisher | Universidad del Rosario | spa |
dc.publisher.department | Escuela de Medicina y Ciencias de la Salud | spa |
dc.publisher.program | Especialización en Infectología | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 2.5 Colombia | spa |
dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
dc.rights.acceso | Abierto (Texto Completo) | spa |
dc.rights.licencia | EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos. | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
dc.source.bibliographicCitation | Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med [Internet]. 2015;373(15):1445–56. Available from: http://www.nejm.org/doi/pdf/10.1056/NEJMra1315399 | spa |
dc.source.bibliographicCitation | Cortés Jorge A, Jaimes Jesús A LAL. Incidencia y prevalencia de candidemia en pacientes críticamente enfermos en Colombia. Rev Chil Infectología. 2013;30(6):599–604. | spa |
dc.source.bibliographicCitation | Antinori S, Milazzo L, Sollima S, Galli M, Corbellino M. Candidemia and invasive candidiasis in adults : A narrative review. Eur J Intern Med [Internet]. 2016;34:21–8. Available from: http://dx.doi.org/10.1016/j.ejim.2016.06.029 | spa |
dc.source.bibliographicCitation | Sarma S, Upadhyay S. Current perspective on emergence, diagnosis and drug resistance in Candida auris. Infect Drug Resist [Internet]. 2017;Volume 10:155–65. Available from: https://www.dovepress.com/current-perspective-on-emergence-diagnosis-and-drug-resistance-in-cand-peer-reviewed-article-IDR | spa |
dc.source.bibliographicCitation | Maldonado NA, Cano LE, De Bedout C, Arbeláez CA, Roncancio G, Tabares ÁM, et al. Association of clinical and demographic factors in invasive candidiasis caused by fluconazole-resistant Candida species: A study in 15 hospitals, Medellín, Colombia 2010-2011. Diagn Microbiol Infect Dis. 2014;79(2):280–6. | spa |
dc.source.bibliographicCitation | Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 2014;20(6):5–10. | spa |
dc.source.bibliographicCitation | Neofytos D, Lu K H-SA et al. Epidemiology, outcomes, and risk factors of invasive fungal infections in adult patients with acute myelogenous leukemia after induction chemotherapy. Diagn Microbiol Infect Dis. 2013;75(2):145–9. | spa |
dc.source.bibliographicCitation | Colombo AL, Nucci M PB et al. Epidemiology of candidemia in Brazil: a nationwide sentinel surveillance of candidemia in eleven medical centers. J Clin Microbiogy. 2006;44:2816–23. | spa |
dc.source.bibliographicCitation | Puig-Asensio M, Padilla B G-MJ et al. Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain. Clin Microbiol Infect. 2013;1–10. | spa |
dc.source.bibliographicCitation | Doi AM, Carlos A, Pignatari C, Edmond MB, Marra R, Fernando L, et al. Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program. PLoS One. 2016;11(1):1–9. | spa |
dc.source.bibliographicCitation | Nucci M, Queiroz-Telles F, Tobon AM, Restrepo A CA. Epidemiology of opportunistic fungal infections in Latin America. Clin Infect Dis. 2013;51(5):561–70. | spa |
dc.source.bibliographicCitation | Cortés Jorge A LAL. Incidencia y prevalencia de candidemia en pacientes críticamente enfermos en Colombia. Rev Chil Infectología. 2013;30(6):599–604. | spa |
dc.source.bibliographicCitation | Alberto J, Reyes P, Hernando C, Isabel S, Rivas P, Casas CA, et al. Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá , Colombia. Brazilian J Infect Dis [Internet]. 2014;18(6):631–7. | spa |
dc.source.bibliographicCitation | Pfaller MA, Diekema DJ R et al. Results from the ARTEMIS DISK global antifungal surveillance study: a 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing. J Clin Microbiogy. 2005;43:5848–5859. | spa |
dc.source.bibliographicCitation | McCarty TP, Pappas PG. Invasive Candidiasis. Infect Dis Clin North Am [Internet]. 2016;30(1):103–24. Available from: http://dx.doi.org/10.1016/j.idc.2015.10.013 | spa |
dc.source.bibliographicCitation | Rodrigues CF, Silva S, Henriques M. Candida glabrata: A review of its features and resistance. Eur J Clin Microbiol Infect Dis. 2014;33(5):673–88. | spa |
dc.source.bibliographicCitation | Colombo AL, Júnior JNDA, Slavin MA, Chen SC, Sorrell TC. Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer. Lancet Infect Dis. 2017;1–13. | spa |
dc.source.bibliographicCitation | Playford EG, Lipman J, Jones M et al. Problematic dichotomization of risk for intensive care unit (ICU)-acquired invasive candidiasis: results using a risk-predictive model to categorize 3 levels of risk from a multicenter prospective cohort of Australian ICU patients. Clin Infect Dis. 2016;63(1463–1469). | spa |
dc.source.bibliographicCitation | Chow JK, Golan Y, Ruthazer R, Karchmer AW, Carmeli Y, Lichtenberg D, et al. Factors Associated with Candidemia Caused by Non‐ albicans Candida Species Versus Candida albicans in the Intensive Care Unit. Clin Infect Dis [Internet]. 2008;46(8):1206–13. Available from: https://academic.oup.com/cid/article-lookup/doi/10.1086/529435 | spa |
dc.source.bibliographicCitation | Garnacho-Montero J, Díaz-Martín A, García-Cabrera E, Pérez De Pipaón MR, Hernández-Caballero C, Aznar-Martín J, et al. Risk factors for fluconazole-resistant candidemia. Antimicrob Agents Chemother. 2010;54(8):3149–54. | spa |
dc.source.bibliographicCitation | Dimopoulos G, Ntziora F, Rachiotis G, Armaganidis A, Falagas ME. Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: Differences in risk factors and outcome. Anesth Analg. 2008;106(2):523–9. | spa |
dc.source.bibliographicCitation | Gong X, Luan T, Wu X, Li G, Qiu H, Kang Y, et al. Invasive candidiasis in intensive care units in China: Risk factors and prognoses of Candida albicans and non-albicans Candida infections. Am J Infect Control [Internet]. 2016;44(5):e59–63. Available from: http://dx.doi.org/10.1016/j.ajic.2015.11.028 | spa |
dc.source.bibliographicCitation | Puig-Asensio M, Pemán J, Zaragoza R et al. Impact of therapeutic strategies on the prognosis of candidemia in the ICU. Crit Care Med. 2014;42:1423–32. | spa |
dc.source.bibliographicCitation | Cataldi S, Guelfand L, Maldonado I, Arechavala A. Evaluación del sistema Vitek 2 para la identifi cación de las principales especies de levaduras del género Candida. Rev Argent Microbiol. 2014;46(2):107–10. | spa |
dc.source.bibliographicCitation | McCoy MH, Relich RF, Davis TE, Schmitt BH. Performance of the filmarray® blood culture identification panel utilized by non-expert staff compared with conventional microbial identification and antimicrobial resistance gene detection from positive blood cultures. J Med Microbiol. 2016;65(7):619–25. | spa |
dc.source.bibliographicCitation | Lacroix C, Gicquel A, Sendid B, Meyer J, Accoceberry I, François N, et al. Evaluation of two matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems for the identification of Candida species. Clin Microbiol Infect. 2014;20(2):153–8. | spa |
dc.source.bibliographicCitation | Bourassa L, Butler-Wu SM. MALDI-TOF mass spectrometry for microorganism identification. Methods Microbiol. 2015;42:37–85. | spa |
dc.source.bibliographicCitation | Kathuria S, Singh PK, Sharma C, Prakash A, Masih A, Kumar A, et al. Multidrug-resistant Candida auris misidentified as Candida haemulonii: Characterization by matrix-assisted laser desorption ionization-time of flight mass spectrometry and DNA sequencing and its antifungal susceptibility profile variability by vitek 2, CLSI broth microdilution, and etest method. J Clin Microbiol. 2015;53(6):1823–30. | spa |
dc.source.bibliographicCitation | Albataineh MT, Sutton DA, Fothergill AW, Wiederhold NP. Update from the Laboratory: Clinical Identification and Susceptibility Testing of Fungi and Trends in Antifungal Resistance. Infect Dis Clin North Am. 2016;30(1):13–35. | spa |
dc.source.bibliographicCitation | Tapia P. C V. Actualización en pruebas de susceptibilidad antifúngica. Rev Chil Infect. 2009;26(2):144–50 | spa |
dc.source.bibliographicCitation | Alexander BD, Johnson MD, Pfeiffer CD, Jiménez-Ortigosa C, Catania J, Booker R, et al. Increasing echinocandin resistance in candida glabrata: Clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin Infect Dis. 2013;56(12):1724–32. | spa |
dc.source.bibliographicCitation | Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2015;62(4):e1–50. | spa |
dc.source.bibliographicCitation | Jimenez, Luisa Fernanda Varón ML. Prevalencia de candidemia por Candida albicans y Candida no albicans en el hospital universitario de la samaritana 2008-20. Universidad de la Sabana; 2012. | spa |
dc.source.bibliographicCitation | Breda GL, Tuon FF, Meis JF, Herkert PF, Hagen F, de Oliveira LZ, et al. Breakthrough candidemia after the introduction of broad spectrum antifungal agents: A 5-year retrospective study. Med Mycol [Internet]. 2017;(January):1–10. Available from: https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy/myx077/4372444 | spa |
dc.source.bibliographicCitation | Bouza E, Burillo A, Muñoz P, Guinea J, Marín M, Rodríguez-Créixems M. Mixed bloodstream infections involving bacteria and Candida spp. J Antimicrob Chemother. 2013;68(8):1881–8. | spa |
dc.source.bibliographicCitation | Kim SH, Yoon YK, Kim MJ, Sohn JW. Risk factors for and clinical implications of mixed Candida/bacterial bloodstream infections. Clin Microbiol Infect. 2013;19(1):62–8. | spa |
dc.source.bibliographicCitation | Klotz SA, Chasin BS, Powell B, Gaur NK, Lipke PN. Polymicrobial bloodstream infections involving Candida species: analysis of patients and review of the literature. Diagn Microbiol Infect Dis. 2007;59(4):401–6. | spa |
dc.source.bibliographicCitation | Pfaller MA, Moet GJ, Messer SA, Jones RN, Castanheira M. Candida bloodstream infections: Comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009. Antimicrob Agents Chemother. 2011;55(2):561–6. | spa |
dc.source.bibliographicCitation | Ahmed A, Azim A, Baronia AK, Marak KRSK, Gurjar M. Risk prediction for invasive candidiasis. Indian J Crtical Care Med. 2014;18(10):682–8. | spa |
dc.source.instname | instname:Universidad del Rosario | spa |
dc.source.reponame | reponame:Repositorio Institucional EdocUR | spa |
dc.subject | Candidemia | spa |
dc.subject | Candidiasis invasiva | spa |
dc.subject | Candida albicans | spa |
dc.subject | Especies no albicans | spa |
dc.subject | Mortalidad | spa |
dc.subject | Factores de riesgo | spa |
dc.subject.ddc | Enfermedades | spa |
dc.subject.keyword | Candidemia | spa |
dc.subject.keyword | Invasive candidiasis | spa |
dc.subject.keyword | Candida albicans | spa |
dc.subject.keyword | Non-albicans species | spa |
dc.subject.keyword | Mortality | spa |
dc.subject.keyword | Risk factors | spa |
dc.subject.lemb | Candidemia | spa |
dc.subject.lemb | Candida albicans | spa |
dc.title | Comparación entre pacientes con Candidemia causada por Candida Albicans versus Candida No-albicans en una población de adultos Fundación Cardio-Infantil, Bogotá, Colombia periodo 2012-2017 | spa |
dc.type | masterThesis | eng |
dc.type.document | Descriptivo observacional retrospectivo | spa |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | |
dc.type.spa | Trabajo de grado | spa |
local.department.report | Escuela de Medicina y Ciencias de la Salud | spa |
Archivos
Bloque original
1 - 1 de 1
Cargando...
- Nombre:
- HerreraDiaz-AnaCatalina.pdf
- Tamaño:
- 695.87 KB
- Formato:
- Adobe Portable Document Format
- Descripción:
- documento completo. tesis