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HLA-DR and DQB1 gene polymorphism in the North-western Colombian population

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dc.creatorCorrea, P.A.spa
dc.creatorWhitworth, W.C.spa
dc.creatorKuffner, T.spa
dc.creatorMcNicholl, J.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-08-19T14:44:00Z
dc.date.available2020-08-19T14:44:00Z
dc.date.created2002-07-22spa
dc.description.abstractHLA?DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north?west Colombia (Medellin) inhabited by the “Paisa”, a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA?DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07?DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA?DRB1 and DQB1 locus were in Hardy–Weinberg equilibrium.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1034/j.1399-0039.2002.590515.x
dc.identifier.issnISSN: 1399-0039
dc.identifier.issnEISSN: 2059-2310
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27809
dc.language.isoengspa
dc.publisherEuropean Federation for Immunogeneticsspa
dc.publisherJohn Wiley & Sonsspa
dc.relation.citationEndPage439
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage436
dc.relation.citationTitleHLA, Tissue Antigens
dc.relation.citationVolumeVol. 59
dc.relation.ispartofHLA, Tissue Antigens, ISSN: 1399-0039;EISSN: 2059-2310, Vol.59, No.5 (May 2002); pp. 436-439spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1034/j.1399-0039.2002.590515.xspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceHLA, Tissue Antigensspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordColombiaspa
dc.subject.keywordHLA?Class IIspa
dc.subject.keywordPopulation studyspa
dc.subject.keywordPCR?SSPspa
dc.titleHLA-DR and DQB1 gene polymorphism in the North-western Colombian populationspa
dc.title.TranslatedTitlePolimorfismo de los genes HLA-DR y DQB1 en la población del noroeste de Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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