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The GPI-anchored 6-Cys Protein Pv12 is Present in Detergent-resistant Microdomains of Plasmodium vivax Blood Stage Schizonts

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dc.creatorMoreno-Pérez, Darwin A.spa
dc.creatorAreiza-Rojas, Rafaelspa
dc.creatorFlórez-Buitrago, Ximenaspa
dc.creatorSilva, Yolandaspa
dc.creatorPatarroyo, Manuel E.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-25T23:58:37Z
dc.date.available2020-05-25T23:58:37Z
dc.date.created2013spa
dc.description.abstractPlasmodium vivax malaria remains one of the tropical diseases causing an enormous burden on global public health. Several proteins located on this parasite species' merozoite surface have been considered the most suitable antigens for being included in an anti-malarial vaccine, given the functional role they play during the parasite's interaction with red blood cells. The present study identifies and characterizes the P. vivax Pv12 surface protein which was evaluated by using molecular biology and immunochemistry assays; its antigenic potential was also examined in natural and experimental P. vivax malaria infections. The P. vivax VCG-1 strain Pv12 gene encodes a 362 amino acid-long protein exhibiting a signal peptide, a glycosylphosphatidylinositol (GPI) anchor sequence and two 6-Cys domains. The presence of the Pv12 protein on the parasite's surface and its association with detergent-resistant membrane complexes, together with its antigenic potential, supports the notion that this antigen could play an important role as a red blood cell binding ligand. Further studies aimed at establishing the immunogenicity and protection-inducing ability of the Pv12 protein or its products in the Aotus experimental model are thus suggested. © 2012 Elsevier GmbH.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.protis.2012.03.001
dc.identifier.issn14344610
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22896
dc.language.isoengspa
dc.relation.citationEndPage48
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage37
dc.relation.citationTitleProtist
dc.relation.citationVolumeVol. 164
dc.relation.ispartofProtist, ISSN:14344610, Vol.164, No.1 (2013); pp. 37-48spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84872275577&doi=10.1016%2fj.protis.2012.03.001&partnerID=40&md5=09b9b46cd5997cbd2f68e4ddad0557c7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordParasite antigenspa
dc.subject.keywordprotozoaneng
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalspa
dc.subject.keywordArticlespa
dc.subject.keywordCell membranespa
dc.subject.keywordChemistryspa
dc.subject.keywordDna sequencespa
dc.subject.keywordErythrocytespa
dc.subject.keywordGeneticsspa
dc.subject.keywordHaplorhinispa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordMolecular geneticsspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordParasitologyspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtein tertiary structurespa
dc.subject.keywordSchizontspa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordDnaeng
dc.subject.keywordErythrocytesspa
dc.subject.keywordHaplorhinispa
dc.subject.keywordMembrane microdomainsspa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtein structureeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSchizontsspa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordSequence analysiseng
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keyword6-cys domainspa
dc.subject.keywordAntigenspa
dc.subject.keywordDetergent-resistant membranespa
dc.subject.keywordGlycosylphosphatidylinositol-anchorspa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivax.spa
dc.titleThe GPI-anchored 6-Cys Protein Pv12 is Present in Detergent-resistant Microdomains of Plasmodium vivax Blood Stage Schizontsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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