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Occurrence of blastocystis in patients with clostridioides difficile infection

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dc.creatorVega, Lauraspa
dc.creatorHerrera, Giovannyspa
dc.creatorMuñoz, Marinaspa
dc.creatorPatarroyo, Manuel A.
dc.creatorRamírez, Juan David
dc.date.accessioned2020-05-25T23:57:54Z
dc.date.available2020-05-25T23:57:54Z
dc.date.created2020spa
dc.description.abstractClostridiodes difficile comprises a public-health threat that has been understudied in Colombia. Hypervirulent strains of C. difficile harbor multiple toxins, can be easily spread, and can have their onset of disease within healthcare facilities (HCFO) and the community (CO). Studies have shown that a disrupted microbiota (e.g., dysbiosis) may allow C. difficile infection (CDI). It has been suggested that dysbiosis prevents colonization by the anaerobic eukaryote Blastocystis, possibly due to an increase in luminal oxygen tension. No study has found co-occurrence of CDI and Blastocystis. Therefore, we aimed to determine the frequencies of C. difficile and Blastocystis infection/colonization in 220 diarrheal fecal samples. Molecular detection by PCR for both microorganisms was performed, with descriptive analyses of four variables (CDI detection, determination of C. difficile toxigenic profiles, Blastocystis detection, and patient site of onset). We demonstrate a significant association between the presence of Blastocystis and CDI, with coinfection found in 61 patients, and show a high frequency of CDI among both HCFO and CO groups. Our results of coinfection frequencies could support hypotheses that suggest Blastocystis can adapt to dysbiosis and oxidative stress. Further, the presence of toxigenic C. difficile occurring outside healthcare facilities shown here raises the alarm for community wide spread. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/pathogens9040283
dc.identifier.issn20760817
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22764
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 4
dc.relation.citationTitlePathogens
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPathogens, ISSN:20760817, Vol.9, No.4 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083484148&doi=10.3390%2fpathogens9040283&partnerID=40&md5=6f39f273a962a57cc59a661ebe6f2957spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGlutamate dehydrogenasespa
dc.subject.keywordRna 16sspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordBlastocystisspa
dc.subject.keywordClostridium difficile infectionspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiagnostic test accuracy studyspa
dc.subject.keywordDiarrheaspa
dc.subject.keywordDna extractionspa
dc.subject.keywordDysbiosisspa
dc.subject.keywordFemalespa
dc.subject.keywordGene amplificationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHospitalizationspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMixed infectionspa
dc.subject.keywordOxidative stressspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorspa
dc.subject.keywordBlastocystisspa
dc.subject.keywordCspa
dc.subject.keywordDifficilespa
dc.subject.keywordCommunity onsetspa
dc.subject.keywordDifficilespa
dc.subject.keywordDysbiosisspa
dc.subject.keywordHealthcare facility onsetspa
dc.subject.keywordToxigenic cspa
dc.titleOccurrence of blastocystis in patients with clostridioides difficile infectionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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