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TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjögren's syndrome

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorCorrea, Paula A.spa
dc.creatorMantilla, Ruben D.spa
dc.creatorArcos-Burgos, Mauriciospa
dc.date.accessioned2020-08-19T14:40:45Z
dc.date.available2020-08-19T14:40:45Z
dc.date.created2002-06spa
dc.description.abstractObjective: Although primary Sjögren's syndrome (pSS) has a worldwide distribution, little data is available on pSS immunogenetics in non-white populations. Thus, we investigated the influence of transporters associated with antigen processing (TAP), human leukocyte antigen (HLA)-DQB1, and HLA-DRB1 gene polymorphism in mestizo Colombian patients with pSS. Methods: In this cross-sectional and controlled study, all patients met the European criteria for classification of pSS. TAP and HLA typing was performed by polymerase chain reaction techniques. Genetic data analysis was performed to detect deviations from the expected Hardy-Weinberg (H-W) proportions and to determine the presence of population stratification or subdivision and the existence of linkage disequilibrium between pairs of loci. Results: Seventy-three Colombian patients with pSS (95% women) and 76 healthy controls were studied. Although significant associations were not observed between TAP or HLA polymorphism and disease, strong linkage disequilibrium among the loci TAP2 and DQB1 was found in patients. Deviations from the H-W expected value were found in the DQB1 locus of patients (P =.02). HLA-DRB1*0301-DQB1*0201 haplotype was associated with more severe histopathologic disease (odds ratio [OR], 15.5; 95% confidence interval [CI], 1.9-129; P =.001) and the presence of anti-Ro (OR, 3.8; 95% CI, 1-15; P =.04) and anti-La antibodies (OR, 4.3; 95% CI, 1.3-14; P =.01). Conclusion: The data show genetic evidence suggesting that, in Colombians, a region immersed or in the vicinity in the HLA class II system is strongly associated with a predisposition to acquire pSS, which is probably located between the TAP2 and HLA-DQB1 locus. Our results confirm that the HLA-DRB1*0301-DQB1*0201 haplotype participates in the pathogenesis of pSS.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1053/sarh.2002.32557
dc.identifier.issnISSN: 0049-0172
dc.identifier.issnEISSN: 1532-866X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27015
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage198
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage191
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 31
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol.31, No.3 (2001); pp. 191-198spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017202000057spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceSeminars in Arthritis and Rheumatismspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordColombiaspa
dc.subject.keywordHuman lymphocyte antigenspa
dc.subject.keywordLinkage disequilibriumspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordTAPspa
dc.titleTAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjögren's syndromespa
dc.title.TranslatedTitlePolimorfismo TAP, HLA-DQB1 y HLA-DRB1 en pacientes colombianos con síndrome de Sjögren primariospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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