Ítem
Acceso Abierto

ABIN1 dysfunction as a genetic basis for lupus nephritis

Mostrar el registro sencillo de la publicación
dc.creatorCaster, Dawn J.spa
dc.creatorKorte, Erik A.spa
dc.creatorNanda, Sambit K.spa
dc.creatorMcLeish, Kenneth R.spa
dc.creatorOliver, Rebecca K.spa
dc.creatorG'Sell, Rachel T.spa
dc.creatorSheehan, Ryan M.spa
dc.creatorFreeman, Darrell W.spa
dc.creatorCoventry, Susan C.spa
dc.creatorKelly, Jennifer A.spa
dc.creatorGuthridge, Joel M.spa
dc.creatorJames, Judith A.spa
dc.creatorSivils, Kathy L.spa
dc.creatorAlarcon-Riquelme, Marta E.spa
dc.creatorScofield, R. Halspa
dc.creatorAdrianto, Indraspa
dc.creatorGaffney, Patrick M.spa
dc.creatorStevens, Anne M.spa
dc.creatorFreedman, Barry I.spa
dc.creatorLangefeld, Carl D.spa
dc.creatorTsao, Betty P.spa
dc.creatorPons-Estel, Bernardo A.spa
dc.creatorJacob, Chaim O.spa
dc.creatorKamen, Diane L.spa
dc.creatorGilkeson, Gary S.spa
dc.creatorBrown, Elizabeth E.spa
dc.creatorAlarcon, Graciela S.spa
dc.creatorEdberg, Jeffrey C.spa
dc.creatorKimberly, Robert P.spa
dc.creatorMartin, Javierspa
dc.creatorMerrill, Joan T.spa
dc.creatorHarley, John B.spa
dc.creatorKaufman, Kenneth M.spa
dc.creatorReveille, John D.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorCriswell, Lindsey A.spa
dc.creatorVila, Luis M.spa
dc.creatorPetri, Michellespa
dc.creatorRamsey-Goldman, Rosalindspa
dc.creatorBae, Sang-Cheolspa
dc.creatorBoackle, Susan A.spa
dc.creatorVyse, Timothy J.spa
dc.creatorNiewold, Timothy B.spa
dc.creatorCohen, Philipspa
dc.creatorPowell, David W.spa
dc.date.accessioned2020-05-25T23:56:39Z
dc.date.available2020-05-25T23:56:39Z
dc.date.created2013spa
dc.description.abstractThe genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-?B is involved. We reported previously that aknockin mouse expressinganin active form of ABIN1 (ABIN1[D485N]) develops lupus-like autoimmune disease and demonstrates enhanced activation of NF-?B and mitogen-activated protein kinases in immune cells after toll-like receptor stimulation. In the current study, we show that ABIN1[D485N] mice develop progressive GN similar to class III and IV lupus nephritis in humans. To investigate the clinical relevance of ABIN1 dysfunction, we genotyped five single-nucleotide polymorphisms in the gene encoding ABIN1, TNIP1, in samples from European-American, African American, Asian, Gullah, and Hispanic participants in the Large Lupus Association Study 2. Comparing cases of systemic lupus erythematosus with nephritis and cases ofsystemic lupus erythematosus without nephritis revealed strong associations with lupus nephritis at rs7708392 in European Americans and rs4958881 in African Americans. Comparing cases of systemic lupus erythematosus with nephritis and healthy controls revealed a stronger association at rs7708392 in European Americans but not at rs4958881 in African Americans. Our data suggest that variants in the TNIP1 gene are associated with the risk for lupus nephritis and could be mechanistically involved in disease development via aberrant regulation of NF-?B and mitogen-activated protein kinase activity. Copyright © 2013 by the American Society of Nephrology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1681/ASN.2013020148
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22476
dc.language.isoengspa
dc.relation.citationEndPage1754
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage1743
dc.relation.citationTitleJournal of the American Society of Nephrology
dc.relation.citationVolumeVol. 24
dc.relation.ispartofJournal of the American Society of Nephrology, Vol.24, No.11 (2013); pp. 1743-1754spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84887052296&doi=10.1681%2fASN.2013020148&partnerID=40&md5=92a52685140adacf0d756894c60962dfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulin enhancer binding proteinspa
dc.subject.keywordMitogen activated protein kinasespa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordinbred c57bleng
dc.subject.keywordknockouteng
dc.subject.keywordToll like receptorspa
dc.subject.keywordA20 binding inhibitor of immunoglobulin enhancer binding protein 1 genespa
dc.subject.keywordAfrican americanspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEuropean americanspa
dc.subject.keywordGenespa
dc.subject.keywordGenotypespa
dc.subject.keywordImmunocompetent cellspa
dc.subject.keywordLupus erythematosus nephritisspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAnimalsspa
dc.subject.keywordDna-binding proteinsspa
dc.subject.keywordFluorescent antibody techniquespa
dc.subject.keywordHumansspa
dc.subject.keywordKidneyspa
dc.subject.keywordLupus nephritisspa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordMiceeng
dc.subject.keywordNf-kappa bspa
dc.subject.keywordPolymorphismeng
dc.titleABIN1 dysfunction as a genetic basis for lupus nephritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1743-full.pdf
Tamaño:
1.98 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos