Ítem
Acceso Abierto

HIV Controllers Exhibit Effective CD8 + T Cell Recognition of HIV-1-Infected Non-activated CD4 + T Cells

Mostrar el registro sencillo de la publicación
dc.creatorMonel, Blandinespa
dc.creatorMcKeon, Annmariespa
dc.creatorLamothe-Molina, Pedrospa
dc.creatorJani, Priyaspa
dc.creatorBoucau, Juliespa
dc.creatorPacheco Nieva, Yovana
dc.creatorJones, R. Bradspa
dc.creatorLe Gall, Sylviespa
dc.creatorWalker, Bruce D.spa
dc.date.accessioned2020-05-26T00:03:57Z
dc.date.available2020-05-26T00:03:57Z
dc.date.created2019spa
dc.description.abstractEven with sustained antiretroviral therapy, resting CD4 + T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV. Here, we demonstrate that CD8 + T cells recognize infected, non-activated CD4 + T cells in the absence of de novo protein production, as measured by immune synapse formation, degranulation, cytokine production, and killing of infected cells. Immune recognition is induced by HLA-I presentation of peptides derived from incoming viral particles, and recognition occurred either following cell-free virus infection or following cell-to-cell spread. CD8 + T cells from HIV controllers mediate more effective immune recognition than CD8 + T cells from progressors. These results indicate that non-activated HIV-infected CD4 + T cells can be targeted by CD8 + T cells directly after HIV entry, before reverse transcription, and thus before the establishment of latency, and suggest a mechanism whereby the immune response may reduce the size of the HIV reservoir. The cure for HIV is not achievable due to HIV reservoirs, mostly in resting CD4 + T cells. Monel et al. show that CD8 + T cells from HIV controllers are able to establish immunological synapses with HIV + resting CD4 + T cells, leading to IFN-?, MIP1-? production, degranulation, and the elimination of the target cells. © 2019 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2019.03.016
dc.identifier.issn22111247
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23642
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage153.e4
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage142
dc.relation.citationTitleCell Reports
dc.relation.citationVolumeVol. 27
dc.relation.ispartofCell Reports, ISSN:22111247, Vol.27, No.1 (2019); pp. 142-153.e4spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063383455&doi=10.1016%2fj.celrep.2019.03.016&partnerID=40&md5=332d50ba72513d6eed03a3e1bef75e1cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordAntigen presentationspa
dc.subject.keywordArticlespa
dc.subject.keywordCD4+ T lymphocytespa
dc.subject.keywordCD8+ T lymphocytespa
dc.subject.keywordColorimetryspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordDegranulationspa
dc.subject.keywordFlow cytometryspa
dc.subject.keywordFluorescence microscopyspa
dc.subject.keywordFluorescence resonance energy transferspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordHuman immunodeficiency virus 1 infectionspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunological synapsespa
dc.subject.keywordLong terminal repeatspa
dc.subject.keywordMolecular recognitionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein cleavagespa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordSynapsespa
dc.subject.keywordVirus entryspa
dc.subject.keywordVirus genomespa
dc.subject.keywordVirus particlespa
dc.subject.keywordCytotoxic T lymphocytesspa
dc.subject.keywordElite controllersspa
dc.subject.keywordGranzymespa
dc.subject.keywordHIVspa
dc.subject.keywordHIV curespa
dc.subject.keywordHLAspa
dc.subject.keywordImmunologic synapsespa
dc.subject.keywordPerforinspa
dc.titleHIV Controllers Exhibit Effective CD8 + T Cell Recognition of HIV-1-Infected Non-activated CD4 + T Cellsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
PIIS2211124719303237.pdf
Tamaño:
3.74 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos