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Risk factors for community acquired urinary tract infections caused by extended spectrum β-lactamase (ESBL)

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dc.contributor.advisorAsmar, Bassim
dc.contributor.advisorAsmar, Bassim
dc.creatorZhu, Frank
dc.creatorRodado Bernal, Maria Paula
dc.creatorNahed, Abdel-Haq
dc.creatorBassim, Asmar
dc.creator.degreeEspecialista en Pediatríaspa
dc.date.accessioned2018-08-17T19:57:49Z
dc.date.available2018-08-17T19:57:49Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractExtended-spectrum βlactamases (ESBLs)are β-lactamases that hydrolyze extended-spectrum cephalosporins with an oxyimino side chain. These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam.Thus ESBLs confer resistance to these antibiotics and related oxyimino-βlactams. In recent years an increasing number of children with community acquired (CA)-UTI due to ESBL-producing organisms, especially E.coli,has been observed at our institution. The primary aim of this study was to determine the frequency of CA-UTIs caused by ESBL-producing bacterial pathogens in children seen at Children’s Hospital of Michigan during 2012-2016 and investigate the characteristics of childrento determine the risk factors associated with these infections. This study is a case control study Patients in the control group were matched by age, gender, and year of the CA-UTI due ESBL-producing E. coli group. Exclusion criteria included positive urine cultures >72 hours after hospitalization, patients with long term care facility stay within the preceding 3 months, postoperativeinfections within 10 days of surgery, and asymptomatic bacteriuria. Each urine culture was included once in the study.If more than one positiveESBL-producing E. coliurine culturewas present, the last clinical record with the least missing data was included. Positive urine culture was defined according to the method of collection of the urine sample. Bag specimens werenot included in the analysis. In midstreamspecimens of urine, UTI was defined as a positive urine culture ≥105CFU/mL or a positive urine culture (104-105CFU/mL) with pyuria of ≥10leukocytes per high power field. In specimens obtained through by bladder catheterization, growth of 104 -105CFU/mL was defined as UTI.Medical records ofpatients with UTI caused by ESBL-producing and non-ESBL producing E coliwere reviewed to obtain information on demographic characteristics, history of hospital visits, clinical findings, urine culturepathogen its antimicrobial susceptibilities, laboratory and imaging studies, comorbidities, treatment modalities,hospital course, complications,and outcome. Information was collected and analyzed for the following potential risk factorsfor ESBL infection: history of previous UTI, anatomic abnormalities of the urinary tract,antibiotic usage in the past 3months,previous hospitalizations,intensive care unit stay,surgeries,underlying neurologic abnormalitiessuch as spina bifidaor neurogenic bladder,previous infections,history of infection with ESBL-producing bacteria or other resistant bacteria,and intermittent urinary bladder catheterization. The results show a incrieasing risk of UTI with previouss use of antibiótics.eng
dc.description.embargo2019-08-17 01:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2019-08-17spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_18308
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18308
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de medicinaspa
dc.publisher.programEspecialización en Pediatríaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectUrinary tract infectionspa
dc.subjectExtended-spectrum βlactamasesspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembInfecciones del tracto urinario en niñosspa
dc.titleRisk factors for community acquired urinary tract infections caused by extended spectrum β-lactamase (ESBL)spa
dc.title.alternativeRisk factors for community acquired urinary tract infections caused by extended spectrum β-lactamase (ESBL)spa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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