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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users

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dc.creatorParaschiv, Simonaspa
dc.creatorBanica, Leontinaspa
dc.creatorNicolae, Ioneliaspa
dc.creatorNiculescu, Iuliaspa
dc.creatorAbagiu, Adrianspa
dc.creatorJipa, Ralucaspa
dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorPingarilho, Martaspa
dc.creatorNeaga, Emilspa
dc.creatorTheys, Kristofspa
dc.creatorLibin, Pieterspa
dc.creatorOtelea, Danspa
dc.creatorAbecasis, Anaspa
dc.date.accessioned2020-05-25T23:58:14Z
dc.date.available2020-05-25T23:58:14Z
dc.date.created2017spa
dc.description.abstractCo-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population. © 2017 Paraschiv et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0185866
dc.identifier.issn19326203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22825
dc.language.isoengspa
dc.publisherPublic Library of Sciencespa
dc.relation.citationIssueNo. 10
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 12
dc.relation.ispartofPLoS ONE, ISSN:19326203, Vol.12, No.10 (2017)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031014330&doi=10.1371%2fjournal.pone.0185866&partnerID=40&md5=5cc32df4804c1ddc68b54146020fb7c9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug dependencespa
dc.subject.keywordEpidemicspa
dc.subject.keywordGenotypespa
dc.subject.keywordHepatitis Cspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virusspa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordMolecular clockspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPrisonspa
dc.subject.keywordRomaniaspa
dc.subject.keywordRomanian (citizen)spa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordAdultspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordDrug usespa
dc.subject.keywordFemalespa
dc.subject.keywordGeneticsspa
dc.subject.keywordHepacivirusspa
dc.subject.keywordHepatitis Cspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordMalespa
dc.subject.keywordPathogenicityspa
dc.subject.keywordTransmissionspa
dc.subject.keywordVirologyspa
dc.subject.keywordAdultspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordDisease Outbreaksspa
dc.subject.keywordDrug Usersspa
dc.subject.keywordFemalespa
dc.subject.keywordGenotypespa
dc.subject.keywordHepacivirusspa
dc.subject.keywordHepatitis Cspa
dc.subject.keywordHIVspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordPhylogenyspa
dc.subject.keywordRomaniaspa
dc.titleEpidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug usersspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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