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Manganese and epilepsy: A systematic review of the literature

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dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.creatorGutierrez-Alvarez, Angela M.spa
dc.creatorMoreno, Carlos B.spa
dc.date.accessioned2020-05-26T00:03:32Z
dc.date.available2020-05-26T00:03:32Z
dc.date.created2007spa
dc.description.abstractManganese is an essential trace element for the development and function of the central nervous system. Alterations in manganese concentrations, whether excessive or deficient, can be accompanied by convulsions. This article represents a systematic review of available quantitative evidence that might clarify this issue. We searched The Cochrane Library, Medline and LILACS databases from January 1966 through June 2006 and reviewed all resulting English and Spanish language publications, as well as those possibly relevant in other languages based on their abstracts. The final selection included for this review comprises all investigations in humans and animals that compared manganese levels in any tissue of a group with spontaneous or induced convulsions (with or without antiepileptic treatment) and a convulsion-free control group. The literature search identified thirteen publications since then relevant to the issue, four of which failed to meet our criteria for inclusion. Of the remaining nine, six were in humans and three in rodents. At present, there is no satisfactory explanation for the relationship between low manganese levels and the presence of convulsions. There is a documented correlation between low blood manganese levels and the presence of convulsions in both humans and animals. The lack of evidence indicating whether this is a cause or an effect of the convulsions clearly justifies more detailed follow-up investigations in humans. © 2006 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.brainresrev.2006.10.002
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23602
dc.language.isoengspa
dc.relation.citationEndPage336
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage332
dc.relation.citationTitleBrain Research Reviews
dc.relation.citationVolumeVol. 53
dc.relation.ispartofBrain Research Reviews, Vol.53, No.2 (2007); pp. 332-336spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33846598852&doi=10.1016%2fj.brainresrev.2006.10.002&partnerID=40&md5=5ecb3f405d52d24226ad5a9f2b0e9d0bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnticonvulsive agentspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordManganesespa
dc.subject.keywordValproic acidspa
dc.subject.keywordBibliographic databasespa
dc.subject.keywordCochrane libraryspa
dc.subject.keywordCorrelation analysisspa
dc.subject.keywordDisorders of mitochondrial functionsspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHumanspa
dc.subject.keywordMedical literaturespa
dc.subject.keywordMedlinespa
dc.subject.keywordMineral intakespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPublicationspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordTissue levelspa
dc.subject.keywordAnimalsspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHumansspa
dc.subject.keywordManganesespa
dc.subject.keywordMedlinespa
dc.subject.keywordEpilepsyspa
dc.subject.keywordManganesespa
dc.subject.keywordNervous system physiologyspa
dc.subject.keywordSeizurespa
dc.subject.keywordTrace elementspa
dc.titleManganese and epilepsy: A systematic review of the literaturespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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