Ítem
Acceso Abierto

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

Mostrar el registro sencillo de la publicación
dc.creatorCastiblanco, Johnspa
dc.creatorVarela, Diana-Cristinaspa
dc.creatorCastaño-Rodríguez, Nataliaspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorHincapié, María-Eugeniaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:11:31Z
dc.date.available2020-05-26T00:11:31Z
dc.date.created2008spa
dc.description.abstractBackground and aim: The involvement of Toll-like receptor (TLR)-mediated pathways in infectious and autoimmunity has been suggested. The MyD88 adaptor-like (Mal) protein, also known as the TIR domain-containing adaptor protein (TIRAP), is implicated in the TLR2- and TLR4-mediated MyD88-dependent signaling pathway. The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D). Methods: This was a case-control and family based association study in which 1325 individuals from a well-defined Colombian population were involved. TIRAP (MAL) S180L genotyping was done by using a polymerase chain reaction-restriction fragment length polymorphism technique and by direct sequencing. Results: Leu180 allele was found to be a protective factor against developing TB (odd ratio (OR): 0.53, 95% confidence interval (CI): 0.29-0.97) and SLE (OR: 0.29, 95% CI: 0.14-0.61) while no significant influence on RA, pSS and T1D was observed. Conclusion: These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response. © 2008 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2008.03.001
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24308
dc.language.isoengspa
dc.relation.citationEndPage544
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage541
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 8
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.8, No.5 (2008); pp. 541-544spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-46749097334&doi=10.1016%2fj.meegid.2008.03.001&partnerID=40&md5=b93dfe0b884d0fc662eb3b63f8c7ec7dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdaptor proteinspa
dc.subject.keywordLeucinespa
dc.subject.keywordsystemiceng
dc.subject.keywordinterleukin-1eng
dc.subject.keywordgeneticeng
dc.subject.keywordToll like receptor domain containing adaptor proteinspa
dc.subject.keywordAdultspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordCase control studyspa
dc.subject.keywordColombiaspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFamilyspa
dc.subject.keywordFemalespa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtectionspa
dc.subject.keywordRestriction fragment length polymorphismspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTuberculosisspa
dc.subject.keywordAdultspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordMembrane glycoproteinsspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.subject.keywordTuberculosisspa
dc.subject.keywordMalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTirapspa
dc.subject.keywordTuberculosisspa
dc.subject.keywordType 1 diabetes mellitusspa
dc.titleTIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
TIRAP_MAL_S180L_polymorphism_is_a_common.pdf
Tamaño:
1.14 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos